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Fascin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='6i0z' size='340' side='right' caption='Human fascin complex with anti-metastatic inhibitor (PDB id 6i0z).' scene=''> == Function == '''Fascin''' (FASC) is an...) |
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| - | + | <StructureSection load='6i0z' size='400' side='right' caption='Human fascin complex with anti-metastatic inhibitor (PDB id [[6i0z]]).' scene='86/862889/Cv/1'> | |
| - | <StructureSection load='6i0z' size=' | + | |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | + | FASC 3D structure shows it to contain <scene name='86/862889/Cv/2'>4 β-trefoil domains</scene>. A complex between FASC and an anti-metastatic agent shows the <scene name='86/862889/Cv/3'>inhibitor binding to domains 1 and 2</scene> <ref>PMID:30773430</ref>. <scene name='86/862889/Cv/4'>The anti-metastatic agent is situated in deep pocket</scene>. | |
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</StructureSection> | </StructureSection> | ||
== 3D structures of fascin == | == 3D structures of fascin == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
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Current revision
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3D structures of fascin
1dfc, 3llp, 3p53 - hFASC 1 - human
4gov, 4goy, 4gp0, 4gp3 - hFASC 1 (mutant)
6i0z, 6i17, 6i16, 6i18, 6i11, 6i10, 6i13, 6i12, 6i15, 6i14 - hFASC + anti-metastatic inhibitor
6b0t - hFASC + inhibitor
References
- ↑ Gungor-Ordueri NE, Cheng CY. Fascin - An actin binding and bundling protein in the testis and its role in ectoplasmic specialization dynamics. Spermatogenesis. 2015 Feb 23;5(1):e1002733. doi: 10.1080/21565562.2014.1002733., eCollection 2015 Jan-Apr. PMID:26413410 doi:http://dx.doi.org/10.1080/21565562.2014.1002733
- ↑ Al-Alwan M, Olabi S, Ghebeh H, Barhoush E, Tulbah A, Al-Tweigeri T, Ajarim D, Adra C. Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules. PLoS One. 2011;6(11):e27339. doi: 10.1371/journal.pone.0027339. Epub 2011 Nov 4. PMID:22076152 doi:http://dx.doi.org/10.1371/journal.pone.0027339
- ↑ Qualtrough D, Smallwood K, Littlejohns D, Pignatelli M. The actin-bundling protein fascin is overexpressed in inflammatory bowel disease and may be important in tissue repair. BMC Gastroenterol. 2011 Feb 23;11:14. doi: 10.1186/1471-230X-11-14. PMID:21345224 doi:http://dx.doi.org/10.1186/1471-230X-11-14
- ↑ Francis S, Croft D, Schuttelkopf AW, Parry C, Pugliese A, Cameron K, Claydon S, Drysdale M, Gardner C, Gohlke A, Goodwin G, Gray CH, Konczal J, McDonald L, Mezna M, Pannifer A, Paul NR, Machesky L, McKinnon H, Bower J. Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg Med Chem Lett. 2019 Jan 30. pii: S0960-894X(19)30056-3. doi:, 10.1016/j.bmcl.2019.01.035. PMID:30773430 doi:http://dx.doi.org/10.1016/j.bmcl.2019.01.035
