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3o2y

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{{Seed}}
 
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[[Image:3o2y.jpg|left|200px]]
 
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==Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid==
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The line below this paragraph, containing "STRUCTURE_3o2y", creates the "Structure Box" on the page.
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<StructureSection load='3o2y' size='340' side='right'caption='[[3o2y]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o2y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3O2Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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-->
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o19|3o19]], [[3o22|3o22]]</td></tr>
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{{STRUCTURE_3o2y| PDB=3o2y | SCENE= }}
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3o2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2y OCA], [http://pdbe.org/3o2y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o2y RCSB], [http://www.ebi.ac.uk/pdbsum/3o2y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o2y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN]] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o2/3o2y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o2y ConSurf].
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<div style="clear:both"></div>
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===Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid===
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==See Also==
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*[[Prostaglandin D synthase|Prostaglandin D synthase]]
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== References ==
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==About this Structure==
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<references/>
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3O2Y is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2Y OCA].
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__TOC__
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[[Category: Homo sapiens]]
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</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Prostaglandin-D synthase]]
[[Category: Prostaglandin-D synthase]]
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[[Category: Li, Y.]]
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[[Category: Li, Y]]
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[[Category: Liu, Z J.]]
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[[Category: Liu, Z J]]
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[[Category: Shaw, N.]]
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[[Category: Shaw, N]]
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[[Category: Zhang, R.]]
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[[Category: Zhang, R]]
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[[Category: Zhao, Y.]]
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[[Category: Zhao, Y]]
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[[Category: Zhou, Y.]]
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[[Category: Zhou, Y]]
[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Lipocalin]]
[[Category: Lipocalin]]
[[Category: Prostaglandin synthase]]
[[Category: Prostaglandin synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:48:44 2010''
 

Current revision

Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid

PDB ID 3o2y

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