Sodium-hydrogen exchange regulatory factor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
== Function ==
== Function ==
-
'''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>.
+
'''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' or '''Na+/H+ exchange regulatory cofactor NHE-RF1''' or '''NHERF''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>.
== Relevance ==
== Relevance ==
Line 20: Line 20:
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*Sodium-hydrogen exchange regulatory factor 1
+
*Sodium-hydrogen exchange regulatory factor 1; Domains – PDZ 1 11-120; PDZ 2 150-235; PDZ 3 246-335; PDZ 4 375-459
**[[1g9o]], [[1gq5]], [[1gq4]] – hNHERF-1 PDZ 1 domain – human <br />
**[[1g9o]], [[1gq5]], [[1gq4]] – hNHERF-1 PDZ 1 domain – human <br />
Line 45: Line 45:
**[[4q2p]] – hNHERF-3 PDZ 2 domain/phage peptide <br />
**[[4q2p]] – hNHERF-3 PDZ 2 domain/phage peptide <br />
**[[2eei]] – mNHERF-3 PDZ 2 domain - NMR<br />
**[[2eei]] – mNHERF-3 PDZ 2 domain - NMR<br />
-
**[[3r68]] – mNHERF-3 PDZ 3 domain<br />
 
-
**[[2d90]] – mNHERF-3 PDZ 3 domain - NMR<br />
 
**[[2v90]] – hNHERF-3 PDZ 3 domain <br />
**[[2v90]] – hNHERF-3 PDZ 3 domain <br />
**[[3r69]] – mNHERF-3 PDZ 3 domain/HDL receptor<br />
**[[3r69]] – mNHERF-3 PDZ 3 domain/HDL receptor<br />
**[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br />
**[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br />
 +
**[[3r68]] – mNHERF-3 PDZ 3 domain<br />
 +
**[[2d90]] – mNHERF-3 PDZ 3 domain - NMR<br />
**[[2vsp]] – hNHERF-3 PDZ 4 domain <br />
**[[2vsp]] – hNHERF-3 PDZ 4 domain <br />
-
**[[2edz]] – mNHERF-3 PDZ 4 domain - NMR<br />
 
**[[6ezi]] – hNHERF-3 PDZ 4 domain + peptide transporter peptide<br />
**[[6ezi]] – hNHERF-3 PDZ 4 domain + peptide transporter peptide<br />
**[[4r2z]] – mNHERF-3 PDZ 4 domain <br />
**[[4r2z]] – mNHERF-3 PDZ 4 domain <br />
 +
**[[2edz]] – mNHERF-3 PDZ 4 domain - NMR<br />
}}
}}
== References ==
== References ==

Revision as of 08:30, 5 November 2020

Human NHERF-1 second PDZ domain with CXCR2 peptide chimera (PDB cod 4q3h)

Drag the structure with the mouse to rotate

3D Structures of sodium-hydrogen exchange regulatory factor

Updated on 05-November-2020

References

  1. ↑ Stemmer-Rachamimov AO, Wiederhold T, Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh V, Louis DN. NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas. Am J Pathol. 2001 Jan;158(1):57-62. doi: 10.1016/S0002-9440(10)63944-2. PMID:11141479 doi:http://dx.doi.org/10.1016/S0002-9440(10)63944-2
  2. ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932
  3. ↑ Morris K. Targeting the myocardial sodium-hydrogen exchange for treatment of heart failure. Expert Opin Ther Targets. 2002 Jun;6(3):291-8. doi: 10.1517/14728222.6.3.291 . PMID:12223070 doi:http://dx.doi.org/10.1517/14728222.6.3.291
  4. ↑ Parker MD, Myers EJ, Schelling JR. Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule. Cell Mol Life Sci. 2015 Jun;72(11):2061-74. doi: 10.1007/s00018-015-1848-8. Epub , 2015 Feb 14. PMID:25680790 doi:http://dx.doi.org/10.1007/s00018-015-1848-8
  5. ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Sodium-hydrogen_exchange_regulatory_factor"
Personal tools