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Spectrin

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**[[3f31]] – hSPT a2 chain N-terminal tetramerization domain<br />
**[[3f31]] – hSPT a2 chain N-terminal tetramerization domain<br />
 +
**[[5fwc]], [[5fwb]] - hSPT a2 chain SH3 domain (mutant)<br />
**[[3fb2]] – hSPT a2 chain repeats 15-16 1337-1544<br />
**[[3fb2]] – hSPT a2 chain repeats 15-16 1337-1544<br />
**[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – hSPT a2 chain SH3 domain (mutant)<br />
**[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – hSPT a2 chain SH3 domain (mutant)<br />

Revision as of 10:32, 8 November 2020

Human spectrin α (grey) and β1 chain (green) 3lbx

Drag the structure with the mouse to rotate

3D Structures of Spectrin

Updated on 08-November-2020

References

  1. Das A, Base C, Dhulipala S, Dubreuil RR. Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway. J Cell Biol. 2006 Oct 23;175(2):325-35. PMID:17060500 doi:http://dx.doi.org/10.1083/jcb.200602095
  2. Coetzer T, Palek J, Lawler J, Liu SC, Jarolim P, Lahav M, Prchal JT, Wang W, Alter BP, Schewitz G, et al.. Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis. Blood. 1990 Jun 1;75(11):2235-44. PMID:2346784
  3. Dhermy D, Galand C, Bournier O, Cynober T, Mechinaud F, Tchemia G, Garbarz M. Hereditary spherocytosis with spectrin deficiency related to null mutations of the beta-spectrin gene. Blood Cells Mol Dis. 1998 Jun;24(2):251-61. PMID:9714702 doi:http://dx.doi.org/10.1006/bcmd.1998.0190

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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