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6bpi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates== | |
| + | <StructureSection load='6bpi' size='340' side='right'caption='[[6bpi]], [[Resolution|resolution]] 1.64Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6bpi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BPI FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=E2G:'>E2G</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6au2|6au2]], [[6au3|6au3]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpi OCA], [http://pdbe.org/6bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bpi RCSB], [http://www.ebi.ac.uk/pdbsum/6bpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Histone-lysine N-methyltransferase]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: BROWN, P J]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: CORLESS, V]] | ||
| + | [[Category: DIAZ, D B]] | ||
| + | [[Category: DOBROVETSKY, E]] | ||
| + | [[Category: DONG, A]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: FRYE, S]] | ||
| + | [[Category: IQBAL, A]] | ||
| + | [[Category: KENNEDY, S]] | ||
| + | [[Category: LIEW, S K]] | ||
| + | [[Category: MADER, P]] | ||
| + | [[Category: Mendoza-Sanchez, R]] | ||
| + | [[Category: SCHAPIRA, M]] | ||
| + | [[Category: SENA, C C.DELA]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: SMIL, D]] | ||
[[Category: Santhakumar, V]] | [[Category: Santhakumar, V]] | ||
| - | [[Category: | + | [[Category: TEMPEL, W]] |
| - | [[Category: | + | [[Category: VEDADI, M]] |
| - | [[Category: | + | [[Category: YUDIN, A K]] |
| - | + | [[Category: Epigenetic]] | |
| - | + | [[Category: Fragment hit]] | |
| - | + | [[Category: Methyl lysine reader]] | |
| - | + | [[Category: Setdb1 tudor]] | |
| - | + | [[Category: Sgc]] | |
| - | + | [[Category: Transferase]] | |
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Current revision
Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates
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Categories: Histone-lysine N-methyltransferase | Large Structures | Arrowsmith, C H | BROWN, P J | Bountra, C | CORLESS, V | DIAZ, D B | DOBROVETSKY, E | DONG, A | Edwards, A M | FRYE, S | IQBAL, A | KENNEDY, S | LIEW, S K | MADER, P | Mendoza-Sanchez, R | SCHAPIRA, M | SENA, C C.DELA | Structural genomic | SMIL, D | Santhakumar, V | TEMPEL, W | VEDADI, M | YUDIN, A K | Epigenetic | Fragment hit | Methyl lysine reader | Setdb1 tudor | Sgc | Transferase
