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6cov
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==CSP2-l14== | |
| + | <StructureSection load='6cov' size='340' side='right'caption='[[6cov]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6cov]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6COV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6COV FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6cov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cov OCA], [http://pdbe.org/6cov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cov RCSB], [http://www.ebi.ac.uk/pdbsum/6cov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cov ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CSP2_STRPN CSP2_STRPN]] Acts as a pheromone, induces cells to develop competence for genetic transformation. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Streptococcus pneumoniae is an important pathogen that utilizes quorum sensing (QS) to regulate genetic transformation, virulence, and biofilm formation. The competence-stimulating peptide (CSP) is a 17-amino acid signal peptide that is used by S. pneumoniae to trigger QS. S. pneumoniae strains can be divided into two main specificity groups based on the CSP signal they produce (CSP1 or CSP2) and their compatible receptors (ComD1 or ComD2, respectively). Modulation of QS in S. pneumoniae can be achieved by targeting the CSP:ComD interaction using synthetic CSP analogues. However, to rationally design CSP-based QS modulators with enhanced activities, an in-depth understanding of the structural features that are required for receptor binding is needed. Herein, we report a comprehensive in-solution three-dimensional structural characterization of eight CSP1 and CSP2 analogues with varied biological activities using nuclear magnetic resonance spectroscopy. Analysis of these structures revealed two distinct hydrophobic patches required for effective ComD1 and ComD2 binding. | ||
| - | + | Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae.,Yang Y, Cornilescu G, Tal-Gan Y Biochemistry. 2018 Aug 28. doi: 10.1021/acs.biochem.8b00653. PMID:30125091<ref>PMID:30125091</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6cov" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Yang, Y]] | [[Category: Yang, Y]] | ||
| + | [[Category: Csp]] | ||
| + | [[Category: Pneumococcus]] | ||
| + | [[Category: Quorum sensing]] | ||
| + | [[Category: Signaling molecule]] | ||
| + | [[Category: Signaling protein]] | ||
Current revision
CSP2-l14
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