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Symporter

From Proteopedia

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<StructureSection load='4d2c' size='340' side='right' caption='Dipeptide:H+ symporter (grey) complex with dipeptide (yellow), lipid and phosphate (PDB code [[4d2c]])' scene=''>
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<StructureSection load='' size='350' side='right' caption='Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'>
== Function ==
== Function ==
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Symporter (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>.
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'''Symporter''' (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>.
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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Dipeptide:H symporter binds the dipeptide between its N- and C-terminal bundles<ref>PMID:24916388</ref>.
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Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>.
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</StructureSection>
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== 3D Structures of symporter ==
== 3D Structures of symporter ==
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[[Symporter 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*D-xylose-proton symporter
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**[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR />
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**[[4ja3]] – EcSymp (mutant) <BR />
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**[[4gby]] – EcSymp + xylose <BR />
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**[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR />
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*Di-or tripeptide:H+ symporter
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**[[4ja4]], [[4xni]], [[4xnj]], [[4d2b]], [[4aps]], [[5d6k]] – StSymp – ''Streptococcus thermophilus''<BR />
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**[[4d2d]] – StSymp + tripeptide<BR />
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**[[4d2c]], [[5d58]], [[5d59]] – StSymp + dipeptide<BR />
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*Proton:oligopeptide symporter
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**[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR />
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**[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR />
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*Sodium/bile acid symporter
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**[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR />
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**[[4n7x]] – YfSymp (mutant) <BR />
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*L-fucose-proton symporter
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**[[3o7q]] – EcSymp <BR />
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**[[3o7p]] – EcSymp (mutant)<BR />
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*Sodium/glucose symporter
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**[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR />
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**[[3dh4]] – VpSymp + galactose <BR />
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*Sodium/citrate symporter
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**[[5a1s]] – Symp + citrate – ''Salmonella enterica''<BR />
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*Purine/H+ symporter
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**[[5i6c]] – Symp + xanthine – ''Aspergillus nidulans''<BR />
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}}
 
== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code 4d2c)

Drag the structure with the mouse to rotate

References

  1. ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:http://dx.doi.org/10.1210/er.2001-0029
  2. ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
  3. ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:http://dx.doi.org/10.15252/embr.201338403

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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