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Thymidylate synthase 3D structures

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**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]], [[5x5a]], [[5x69]][[3n5g]], [[4kpw]] - hTS – human<br />
**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]], [[4up1]], [[5x5a]], [[5x69]][[3n5g]], [[4kpw]] - hTS – human<br />
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]], [[5x4w]], [[5x4x]], [[5x4y]], [[6qyq]] – hTS (mutant)<br />
**[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]], [[5x4w]], [[5x4x]], [[5x4y]], [[6qyq]] – hTS (mutant)<br />
-
**[[3ihi]], [[6qyj]] – mTS – mouse<br />
+
**[[3ihi]] – mTS – mouse<br />
**[[4iqb]] – nTS – nematode<br />
**[[4iqb]] – nTS – nematode<br />
 +
**[[6k7q]] – sTS - shrimp<br />
**[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
**[[3tms]], [[1tjs]], [[1f4b]], [[2ftq]] – EcTS – ''Escherichia coli''<br />
**[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
**[[1ajm]], [[1bq2]], [[1qqq]], [[1ev5]], [[1ev8]], [[1evf]], [[1evg]], [[1ffl]], [[2g8x]], [[2ftn]] - EcTS (mutant) <br />
Line 22: Line 23:
**[[4xse]] - VvTS – Varicella-zoster virus<br />
**[[4xse]] - VvTS – Varicella-zoster virus<br />
**[[6auj]] - TS – ''Elizabethkingia anophelis''<br />
**[[6auj]] - TS – ''Elizabethkingia anophelis''<br />
 +
**[[7cc8]] - wssvTS – white spot syndrome virus<br />
-
*Thymidylate synthase binary complex
+
*Thymidylate synthase binary complex with UMP
**[[6qsh]] - hTS + dUMP<br />
**[[6qsh]] - hTS + dUMP<br />
Line 29: Line 31:
**[[6qxg]] - hTS + fluoro-dUMP<br />
**[[6qxg]] - hTS + fluoro-dUMP<br />
**[[3h9k]] - hTS (mutant) + fluoro-dUMP
**[[3h9k]] - hTS (mutant) + fluoro-dUMP
 +
**[[4e5o]] - mTS + UMP<br />
 +
**[[4irr]], [[4isw]] – nTS + UMP<br />
 +
**[[5by6]] – TwTS + UMP – Trichina worm<br />
 +
**[[6k7r]] – sTS + UMP<br />
 +
**[[1tdc]], [[1thy]], [[2tdm]], [[5x5d]] – LcTS + UMP<BR />
 +
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
 +
**[[1tdb]] - LcTS + fluoro-UMP<BR />
 +
**[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
 +
**[[1bid]] - EcTS + UMP<BR />
 +
**[[2vet]] - EcTS (mutant) + UMP<BR />
 +
**[[3b9h]] - EcTS + nitro-UMP<BR />
 +
**[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
 +
**[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
 +
**[[6qya]] – EfTS + dUMP – ''Enterococcus faecalis''<br />
 +
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
 +
**[[4h0u]] – CgTS + UMP<br />
 +
**[[4xsc]] - VvTS + d-Uridine derivative <br />
 +
**[[4xsd]] - VvTS + dUMP<br />
 +
 +
*Thymidylate synthase binary complex without UMP
 +
**[[5wrn]] - hTS + CMP<br />
**[[5wrn]] - hTS + CMP<br />
**[[3ob7]] - hTS (mutant) + glutathione<br />
**[[3ob7]] - hTS (mutant) + glutathione<br />
Line 37: Line 60:
**[[4e28]] - hTS + inhibitor<br />
**[[4e28]] - hTS + inhibitor<br />
**[[6r2e]] – hTS (mutant) + folate derivative<br />
**[[6r2e]] – hTS (mutant) + folate derivative<br />
-
**[[4e5o]] - mTS + UMP<br />
 
**[[4ein]] – mTS + substrate analog<br />
**[[4ein]] – mTS + substrate analog<br />
-
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
+
**[[6gyj]] - mTS + phenolphthalein<br />
**[[4psg]] – nTS + inhibitor <br >
**[[4psg]] – nTS + inhibitor <br >
-
**[[4irr]], [[4isw]] – nTS + UMP<br />
 
-
**[[5by6]] – TwTS + UMP – Trichina worm<br />
 
**[[1tmk]] - TS + TMP – yeast<br />
**[[1tmk]] - TS + TMP – yeast<br />
-
**[[1tdc]], [[1thy]], [[2tdm]], [[5x5d]] – LcTS + UMP<BR />
+
**[[1nje]] - LcTS + CMP<BR />
-
**[[1tsv]], [[1tsx]], [[1tsy]], [[1njd]], [[1njb]], [[1vza]], [[1vzb]], [[1jmf]], [[1jmg]], [[1jmh]], [[1jmi]], [[1bo7]], [[1bo8]], [[1bp6]], [[1bpj]], [[1bp0]], [[2g86]], [[2g89]], [[2g8a]], [[2g8d]] - LcTS (mutant) + UMP<BR />
+
-
**[[1vzc]] - LcTS (mutant) + fluoro-UMP<BR />
+
**[[1nja]], [[1njc]] - LcTS (mutant) + CMP<BR />
**[[1nja]], [[1njc]] - LcTS (mutant) + CMP<BR />
-
**[[1nje]] - LcTS + CMP<BR />
 
-
**[[1tdb]] - LcTS + fluoro-UMP<BR />
 
**[[1tsl]], [[1tsm]] - LcTS + inhibitor<br />
**[[1tsl]], [[1tsm]] - LcTS + inhibitor<br />
-
**[[4tmk]], [[5tmp]] - EcTS + inhibitor<br />
+
**[[4tmk]], [[5tmp]], [[1an5]] - EcTS + inhibitor<br />
-
**[[1an5]] - EcTS + inhibitor<br />
+
**[[1fwm]] - EcTS (mutant) + inhibitor<br />
**[[1fwm]] - EcTS (mutant) + inhibitor<br />
-
**[[1bid]] - EcTS + UMP<BR />
+
**[[1aob]], [[1bdu]], [[6nnr]] - EcTS + deoxyuridine derivative<br />
-
**[[1aob]], [[1bdu]] - EcTS + deoxyuridine derivative<br />
+
**[[1f4c]], [[1f4e]] - EcTS + tosyl-proline derivative<br />
**[[1f4c]], [[1f4e]] - EcTS + tosyl-proline derivative<br />
**[[1f4d]] - EcTS (mutant) + tosyl-proline derivative<br />
**[[1f4d]] - EcTS (mutant) + tosyl-proline derivative<br />
**[[1f4f]], [[1f4g]] - EcTS + glutamyl-proline derivative<br />
**[[1f4f]], [[1f4g]] - EcTS + glutamyl-proline derivative<br />
-
**[[2vet]] - EcTS (mutant) + UMP<BR />
+
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate<br />
-
**[[3b9h]] - EcTS + nitro-UMP<BR />
+
-
**[[3bfi]] - EcTS (mutant) + nitro-UMP<BR />
+
-
**[[4dq1]] - TS + UMP – ''Staphylococcus aureus''<br />
+
-
**[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br >
+
-
**[[6qya]] – EfTS + dUMP<br />
+
**[[5j7w]] – EfTS + drug <br >
**[[5j7w]] – EfTS + drug <br >
-
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br />
 
-
**[[4h0u]] – CgTS + UMP<br />
 
-
**[[4xsc]] - VvTS + d-Uridine derivative <br />
 
-
**[[4xsd]] - VvTS + dUMP<br />
 
-
*Thymidylate synthase ternary complex
+
*Thymidylate synthase ternary complex with UMP
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<br />
**[[1hvy]], [[1i00]], [[5x5q]], [[5x66]], [[5x67]] - hTS + drug + UMP<br />
-
**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<br />
 
**[[5hs3]], [[6pf6]], [[6pf5]], [[6pf4]], [[6pf3]], [[6ojv]], [[6oju]] - hTS + inhibitor + dUMP<br />
**[[5hs3]], [[6pf6]], [[6pf5]], [[6pf4]], [[6pf3]], [[6ojv]], [[6oju]] - hTS + inhibitor + dUMP<br />
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor + UMP<br />
**[[1ju6]], [[1juj]] - hTS (mutant) + inhibitor + UMP<br />
**[[5fct]] - mTS + inhibitor + fluoro-UMP <br />
**[[5fct]] - mTS + inhibitor + fluoro-UMP <br />
**[[4eb4]] - mTS + drug + UMP<br />
**[[4eb4]] - mTS + drug + UMP<br />
-
**[[6f6z]] - mTS + folate derivative + CMP derivative <br />
+
**[[6gko]] - mTS + phenolphthalein + UMP<br />
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
**[[1rts]], [[2tsr]] - TS + drug + UMP – rat<br />
**[[4iqq]] – nTS + UMP + drug<br />
**[[4iqq]] – nTS + UMP + drug<br />
 +
**[[6k7s]] – sTS + UMP + drug<br />
**[[5noo]] - TS + drug + UMP – ''Caenorhabditis elegans''<br />
**[[5noo]] - TS + drug + UMP – ''Caenorhabditis elegans''<br />
-
**[[5m4z]] - TwTS + folate derivative + CMP derivative <br />
+
**[[2tdd]] - LcTS + inhibitor + fluoro-UMP<BR />
-
**[[2tdd]] - LcTS + inhibitor+ fluoro-UMP<BR />
+
**[[1vzd]] - LcTS (mutant) + inhibitor + fluoro-UMP<BR />
-
**[[1vzd]] - LcTS (mutant) + inhibitor+ fluoro-UMP<BR />
+
**[[1vze]], [[1tvu]], [[1tvv]], [[1tvw]] - LcTS (mutant) + inhibitor + UMP<BR />
-
**[[1vze]], [[1tvu]], [[1tvv]], [[1tvw]] - LcTS (mutant) + inhibitor+ UMP<BR />
+
**[[1lca]], [[1lce]], [[3bnz]] - LcTS + inhibitor + UMP<BR />
-
**[[1lca]], [[1lce]], [[3bnz]] - LcTS + inhibitor+ UMP<BR />
+
-
**[[1lcb]] - LcTS + inhibitor+ TMP<BR />
+
**[[3byx]], [[3bz0]], [[3c06]], [[3c0a]], [[3ijz]], [[3ik0]], [[3ik1]] - LcTS + phthalimidic derivative + UMP<BR />
**[[3byx]], [[3bz0]], [[3c06]], [[3c0a]], [[3ijz]], [[3ik0]], [[3ik1]] - LcTS + phthalimidic derivative + UMP<BR />
-
**[[1tys]] - EcTS + inhibitor+ TMP<BR />
+
**[[2bbq]], [[2tsc]], [[1kce]], [[1trg]], [[1kzi]], [[4isk]], [[4lrr]], [[1syn]], [[1tsd]], [[1jtq]], [[1jtu]], [[1jut]], [[1jg0]], [[2a9w]] - EcTS + inhibitor + UMP<BR />
-
**[[2fto]], [[3bgx]] - EcTS (mutant) + inhibitor+ TMP<BR />
+
**[[1zpr]], [[1aiq]], [[1dna]], [[1bq1]], [[1kzj]], [[2vf0]], [[3b5b]], [[1nce]] - EcTS (mutant) + inhibitor + UMP<BR />
-
**[[1tlc]] - EcTS + inhibitor+ GMP<BR />
+
**[[1tls]], [[1tsn]] - EcTS + inhibitor + fluoro-UMP<BR />
-
**[[1syn]], [[1tsd]] - EcTS + inhibitor+ UMP<BR />
+
**[[3bhl]], [[3bhr]] - EcTS + inhibitor + nitro-UMP<BR />
-
**[[2bbq]], [[2tsc]], [[1kce]], [[1trg]], [[1kzi]], [[4isk]], [[4lrr]] - EcTS + inhibitor+ UMP<BR />
+
**[[1bjg]] - EcTS (mutant) + inhibitor + fluoro-UMP<BR />
-
**[[1zpr]], [[1aiq]], [[1dna]], [[1bq1]], [[1kzj]], [[2vf0]], [[3b5b]] - EcTS (mutant) + inhibitor+ UMP<BR />
+
**[[6cdz]] - EcTS (mutant) + deoxyuridine + UMP<br />
-
**[[1tls]], [[1tsn]] - EcTS + inhibitor+ fluoro-UMP<BR />
+
-
**[[3bhl]], [[3bhr]] - EcTS + inhibitor+ nitro-UMP<BR />
+
-
**[[1bjg]] - EcTS (mutant) + inhibitor+ fluoro-UMP<BR />
+
**[[2kce]], [[1axw]] - EcTS + drug + UMP<BR />
**[[2kce]], [[1axw]] - EcTS + drug + UMP<BR />
-
**[[1jtq]], [[1jtu]], [[1jut]], [[1jg0]], [[2a9w]] - EcTS + inhibitor+ UMP<BR />
 
-
**[[1nce]] - EcTS (mutant) + inhibitor+ UMP<BR />
 
**[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br />
**[[1ddu]], [[1tdu]] - EcTS + deoxyuridine derivative + inhibitor<br />
**[[6cdz]] - EcTS + deoxyuridine + UMP<br />
**[[6cdz]] - EcTS + deoxyuridine + UMP<br />
**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
**[[4gev]] - EcTS + deoxyuridine derivative + cofactor analog<br />
**[[6nnr]] - EcTS + deoxyuridine derivative + folate derivative<br />
**[[6nnr]] - EcTS + deoxyuridine derivative + folate derivative<br />
-
**[[1b02]] - BsTS + inhibitor+ fluoro-UMP<BR />
+
**[[1b02]] - BsTS + inhibitor + fluoro-UMP<BR />
-
**[[1ci7]] - PcTS + inhibitor+ UMP – ''Pneumocystis carinii''<br />
+
**[[1ci7]] - PcTS + inhibitor + UMP – ''Pneumocystis carinii''<br />
-
**[[1f28]] - PcTS + inhibitor+ UMP<BR />
+
**[[1f28]] - PcTS + inhibitor + UMP<BR />
-
**[[2aaz]] - TS + inhibitor+ UMP – ''Filobasidiella neoformans''<br />
+
**[[2aaz]] - TS + inhibitor + UMP – ''Filobasidiella neoformans''<br />
**[[3qj7]] - MtTS + spermine + UMP <br />
**[[3qj7]] - MtTS + spermine + UMP <br />
**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
**[[4fog]] - MtTS + fluoro-UMP + methy-DHF<br />
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
**[[4fox]], [[4fqs]] - MtTS + inhibitor + fluoro-UMP <br />
-
**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
 
**[[6qxs]] - EfTS + fluoro-dUMP + folate derivative<br />
**[[6qxs]] - EfTS + fluoro-dUMP + folate derivative<br />
 +
**[[7cca]] - wssvTS + UMP + methotrexate<br />
 +
 +
*Thymidylate synthase ternary complex without UMP
 +
 +
**[[1e2d]], [[1e2e]], [[1e2f]] - hTS (mutant) + ADP + TMP<br />
 +
**[[6f6z]] - mTS + folate derivative + CMP derivative <br />
 +
**[[4ez8]] – mTS + substrate analog + dihydrofolate<br />
 +
**[[5m4z]] - TwTS + folate derivative + CMP derivative <br />
 +
**[[1lcb]] - LcTS + inhibitor + TMP<BR />
 +
**[[1tys]] - EcTS + inhibitor + TMP<BR />
 +
**[[2fto]], [[3bgx]] - EcTS (mutant) + inhibitor + TMP<BR />
 +
**[[1tlc]] - EcTS + inhibitor + GMP<BR />
 +
**[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br />
*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]]
*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]]

Revision as of 09:57, 30 November 2020

3D structures of thymidylate synthase

Updated on 30-November-2020 - For a general description of the protein see Thymidylate synthase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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