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6v8g
From Proteopedia
(Difference between revisions)
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==GltPh mutant - Y204L A345V V366A== | ==GltPh mutant - Y204L A345V V366A== | ||
| - | <StructureSection load='6v8g' size='340' side='right'caption='[[6v8g]]' scene=''> | + | <StructureSection load='6v8g' size='340' side='right'caption='[[6v8g]], [[Resolution|resolution]] 3.38Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V8G FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6v8g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V8G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6V8G FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8g OCA], [http://pdbe.org/6v8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v8g RCSB], [http://www.ebi.ac.uk/pdbsum/6v8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8g ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH1295 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6v8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v8g OCA], [http://pdbe.org/6v8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v8g RCSB], [http://www.ebi.ac.uk/pdbsum/6v8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v8g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO]] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Boudker O]] | + | [[Category: Pyrococcus horikoshii]] |
| - | [[Category: Huysmans | + | [[Category: Boudker, O]] |
| + | [[Category: Huysmans, G H.M]] | ||
| + | [[Category: Aspartate transporter]] | ||
| + | [[Category: Fast mutant]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Substrate bound]] | ||
Revision as of 08:11, 2 December 2020
GltPh mutant - Y204L A345V V366A
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