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6xmx
From Proteopedia
(Difference between revisions)
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==Cryo-EM structure of BCL6 bound to BI-3802== | ==Cryo-EM structure of BCL6 bound to BI-3802== | ||
| - | <StructureSection load='6xmx' size='340' side='right'caption='[[6xmx]]' scene=''> | + | <StructureSection load='6xmx' size='340' side='right'caption='[[6xmx]], [[Resolution|resolution]] 3.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XMX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XMX FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xmx]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XMX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XMX FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xmx OCA], [http://pdbe.org/6xmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xmx RCSB], [http://www.ebi.ac.uk/pdbsum/6xmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xmx ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U52:2-[6-[[5-chloranyl-2-[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]pyrimidin-4-yl]amino]-1-methyl-2-oxidanylidene-quinolin-3-yl]oxy-~{N}-methyl-ethanamide'>U52</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL6, BCL5, LAZ3, ZBTB27, ZNF51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xmx OCA], [http://pdbe.org/6xmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xmx RCSB], [http://www.ebi.ac.uk/pdbsum/6xmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xmx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Burman | + | [[Category: Burman, S S.R]] |
| - | [[Category: Fischer | + | [[Category: Fischer, E S]] |
| - | [[Category: Hunkeler M]] | + | [[Category: Hunkeler, M]] |
| - | [[Category: Nowak | + | [[Category: Nowak, R P]] |
| - | [[Category: Yoon H]] | + | [[Category: Yoon, H]] |
| + | [[Category: Degrader]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription factor]] | ||
Revision as of 08:13, 2 December 2020
Cryo-EM structure of BCL6 bound to BI-3802
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