This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7ahk
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of the outward-facing state of the substrate-free Na+-only bound glutamate transporter homolog GltPh== | ==Crystal structure of the outward-facing state of the substrate-free Na+-only bound glutamate transporter homolog GltPh== | ||
| - | <StructureSection load='7ahk' size='340' side='right'caption='[[7ahk]]' scene=''> | + | <StructureSection load='7ahk' size='340' side='right'caption='[[7ahk]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AHK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7AHK FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ahk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AHK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7AHK FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ahk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ahk OCA], [http://pdbe.org/7ahk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ahk RCSB], [http://www.ebi.ac.uk/pdbsum/7ahk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ahk ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH1295 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 'Pyrococcus shinkaii'])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ahk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ahk OCA], [http://pdbe.org/7ahk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ahk RCSB], [http://www.ebi.ac.uk/pdbsum/7ahk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ahk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLT_PYRHO GLT_PYRHO]] Sodium-dependent, high-affinity amino acid transporter that mediates aspartate uptake (PubMed:17435767, PubMed:19380583, PubMed:17230192, Ref.11). Has only very low glutamate transport activity (PubMed:19380583, PubMed:17230192). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions, resulting in electrogenic transport (PubMed:17435767, PubMed:19380583, Ref.11). Na(+) binding enhances the affinity for aspartate (PubMed:19380583, Ref.11). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:17435767). In contrast to mammalian homologs, transport does not depend on pH or K(+) ions (PubMed:19380583).<ref>PMID:17230192</ref> <ref>PMID:17435767</ref> <ref>PMID:19380583</ref> [PDB:4P19] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Pyrococcus shinkaii]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Alleva C]] | + | [[Category: Alleva, C]] |
| - | [[Category: Astashkin A]] | + | [[Category: Astashkin, A]] |
| - | [[Category: Fahlke C]] | + | [[Category: Fahlke, C]] |
| - | [[Category: Gordeliy V]] | + | [[Category: Gordeliy, V]] |
| - | [[Category: Kovalev K]] | + | [[Category: Kovalev, K]] |
| - | [[Category: Machtens J | + | [[Category: Machtens, J P]] |
| + | [[Category: Aminoacid transport]] | ||
| + | [[Category: Glutamate transporter]] | ||
| + | [[Category: Homologue]] | ||
| + | [[Category: Membrane protein]] | ||
Revision as of 08:19, 2 December 2020
Crystal structure of the outward-facing state of the substrate-free Na+-only bound glutamate transporter homolog GltPh
| |||||||||||
