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1nbw

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Revision as of 08:48, 2 December 2020

Glycerol dehydratase reactivase

Structural highlights

1nbw is a 4 chain structure with sequence from "bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	dhaB4 ("Bacillus pneumoniae" (Schroeter 1886) Flugge 1886), orf2b ("Bacillus pneumoniae" (Schroeter 1886) Flugge 1886)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The function of glycerol dehydratase (GDH) reactivase is to remove damaged coenzyme B(12) from GDH that has suffered mechanism-based inactivation. The structure of GDH reactivase from Klebsiella pneumoniae was determined at 2.4 A resolution by the single isomorphous replacement with anomalous signal (SIR/AS) method. Each tetramer contains two elongated 63 kDa alpha subunits and two globular 14 kDa beta subunits. The alpha subunit contains structural features resembling both GroEL and Hsp70 groups of chaperones, and it appears chaperone like in its interactions with ATP. The fold of the beta subunit resembles that of the beta subunit of glycerol dehydratase, except that it lacks some coenzyme B(12) binding elements. A hypothesis for the reactivation mechanism of reactivase is proposed based on these structural features.

Structure of glycerol dehydratase reactivase: a new type of molecular chaperone.,Liao DI, Reiss L, Turner I, Dotson G Structure. 2003 Jan;11(1):109-19. PMID:12517345^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Liao DI, Reiss L, Turner I, Dotson G. Structure of glycerol dehydratase reactivase: a new type of molecular chaperone. Structure. 2003 Jan;11(1):109-19. PMID:12517345

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nbw"

@@ Line 1: / Line 1: @@
 ==Glycerol dehydratase reactivase==
-<StructureSection load='1nbw' size='340' side='right' caption='[[1nbw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='1nbw' size='340' side='right'caption='[[1nbw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1nbw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NBW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1nbw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NBW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dhaB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886]), orf2b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nbw OCA], [http://pdbe.org/1nbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nbw RCSB], [http://www.ebi.ac.uk/pdbsum/1nbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nbw ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1nbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nbw OCA], [http://pdbe.org/1nbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nbw RCSB], [http://www.ebi.ac.uk/pdbsum/1nbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nbw ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 31: / Line 31: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Dotson, G]]
 [[Category: Liao, D I]]

1nbw

From Proteopedia

Revision as of 08:48, 2 December 2020

Glycerol dehydratase reactivase

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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