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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function of your Protein

SidA acts as both a receptor and an enzyme. As a receptor it extracts metals such as iron and takes it into cells. It is also an enzyme because it uses the FAD in the reactions.

Biological relevance and broader implications

SidA is from Aspergillus fumigatus and is a fungal disease drug target that is involved in the production of hydromate-containing siderophores, that are used by a pathogen to take iron. This protein affects the lungs and can be fatal in humans and animals. Because iron is the host organism, it is sequestered by the iron-building proteins which makes it a restricted nutrient for SidA. This is relevant because they are finding new information about configurational dynamics in flavin-dependent monooxygenases. We are using this to understand all of the different active sites and their conformations during the catalytic cycle. This results in the fine-tuning of inhibitor discovery efforts.

Important amino acids

The important amino acids to pay attention to are Tyr324, Tyr276, Ser325, Asn323, and Asn275. Tyr324 is important because it moves over by 10A and shifts away from the active site. We have a triad which consists of Asn323, -FTyr324, and -Ser325. . This image attacked to residues shows the residue amino acids to pay attention to. Our ligands are displayed in the next section but we see how some are and aren't bound.

Structural highlights

. The ligands it does have are NADPH and FAD and they're bound, just not to the substrate. There are 4 crystal structures formed. The outside green, pink, blue, and yellow show the beta sheets and helices in the secondary structure, about 90% helices and 10% beta. The important parts to recognize are the purple helices.

Other important features

One feature is that that the Pka is 6.0. The charges would either be red or blue and it doesn't look like those are present. The other important feature is that there are . They are clearly marked by four separate colors and show different branches in the middle.

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