1q1v

From Proteopedia

(Difference between revisions)

Revision as of 07:41, 9 December 2020

Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif

Structural highlights

1q1v is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	dek (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[DEK_HUMAN] Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia. Translocation t(6;9)(p23;q34) with NUP214/CAN. It results in the formation of a DEK-CAN fusion gene.

Function

[DEK_HUMAN] Involved in chromatin organization.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The chromatin-associated protein DEK was first identified as a fusion protein in patients with a subtype of acute myelogenous leukemia. It has since become associated with diverse human ailments ranging from cancers to autoimmune diseases. Despite much research effort, the biochemical basis for these clinical connections has yet to be explained. We have identified a structural domain in the C-terminal region of DEK [DEK(309-375)]. DEK(309-375) implies clinical importance because it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. We determined the solution structure of DEK(309-375) by nuclear magnetic resonance spectroscopy, and found it to be structurally homologous to the E2F/DP transcription factor family. On the basis of this homology, we tested whether DEK(309-375) could bind DNA and identified the DNA-interacting surface. DEK presents a hydrophobic surface on the side opposite the DNA-interacting surface. The structure of the C-terminal region of DEK provides insights into the protein function of DEK.

Solution NMR structure of the C-terminal domain of the human protein DEK.,Devany M, Kotharu NP, Matsuo H Protein Sci. 2004 Aug;13(8):2252-9. Epub 2004 Jul 6. PMID:15238633^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hu HG, Scholten I, Gruss C, Knippers R. The distribution of the DEK protein in mammalian chromatin. Biochem Biophys Res Commun. 2007 Jul 13;358(4):1008-14. Epub 2007 May 21. PMID:17524367 doi:10.1016/j.bbrc.2007.05.019
↑ Devany M, Kotharu NP, Matsuo H. Solution NMR structure of the C-terminal domain of the human protein DEK. Protein Sci. 2004 Aug;13(8):2252-9. Epub 2004 Jul 6. PMID:15238633 doi:10.1110/ps.04797104

1 Structural highlights
2 Disease
3 Function
4 Evolutionary Conservation
5 Publication Abstract from PubMed
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q1v"

@@ Line 1: / Line 1: @@
 ==Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif==
-<StructureSection load='1q1v' size='340' side='right' caption='[[1q1v]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='1q1v' size='340' side='right'caption='[[1q1v]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1q1v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q1V FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1q1v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q1V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1Q1V FirstGlance]. <br>
 </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dek ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1v OCA], [http://pdbe.org/1q1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1v RCSB], [http://www.ebi.ac.uk/pdbsum/1q1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1v ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1q1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q1v OCA], [http://pdbe.org/1q1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1q1v RCSB], [http://www.ebi.ac.uk/pdbsum/1q1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1q1v ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 35: / Line 35: @@
 </StructureSection>
 [[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Devany, M]]
 [[Category: Kotharu, N P]]

1q1v

From Proteopedia

Revision as of 07:41, 9 December 2020

Structure of the Oncoprotein DEK: a putative DNA-binding Domain Related to the Winged Helix Motif

Structural highlights

Disease

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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