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Transcriptional activator 3D structures

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Line 11: Line 11:
**[[1ygh]] – yTA histone acetyltransferase domain <br />
**[[1ygh]] – yTA histone acetyltransferase domain <br />
-
*C-Myb transcriptional activator; domains - DBD repeat 1 38-89; DBD repeat 2 90-141; DBD repeat 3 142-193; TAD 291-315
+
*C-Myb transcriptional activator; domains - DBD repeat 1 38-89; DBD repeat 2 90-141; DBD repeat 3 142-193; transcriptional activation (TAD) 291-315
-
**[[1mse]], [[1msf]] – mTA DBD repeat 1,2 + DNA - NMR<br />
+
**[[1mse]], [[1msf]] – mTA DBD repeat 1,2 + DNA - mouse - NMR<br />
-
**[[1mbe]], [[1mbf]] – mTA DBD repeat 1 + DNA – mouse - NMR<br />
+
**[[1mbe]], [[1mbf]] – mTA DBD repeat 1 + DNA - NMR<br />
**[[1mbg]], [[1mbh]] – mTA DBD repeat 2 + DNA - NMR<br />
**[[1mbg]], [[1mbh]] – mTA DBD repeat 2 + DNA - NMR<br />
**[[1mbj]], [[1mbk]] – mTA DBD repeat 3 + DNA - NMR<br />
**[[1mbj]], [[1mbk]] – mTA DBD repeat 3 + DNA - NMR<br />
Line 47: Line 47:
**[[1yak]] – BsTA + pyrimidine derivative<br />
**[[1yak]] – BsTA + pyrimidine derivative<br />
**[[2qcx]] – BsTA (mutant) + pyrimidine derivative<br />
**[[2qcx]] – BsTA (mutant) + pyrimidine derivative<br />
 +
**[[1udd]] – TA – ''Pyrococcus horikishii''<br />
*LasR transcriptional activator or transcriptional regulator LasR
*LasR transcriptional activator or transcriptional regulator LasR
Line 52: Line 53:
**[[6mww]] – PaTA – ''Pseudomonas aeruginosa''<br />
**[[6mww]] – PaTA – ''Pseudomonas aeruginosa''<br />
**[[2uv0]] – PaTA LBD residues 1-173<br />
**[[2uv0]] – PaTA LBD residues 1-173<br />
-
**[[3ix3]] – PaTA LBD + oxo-dodecanoyl-homoserine lactone<br />
+
**[[3ix3]], [[6mvn]], [[6mvm]] – PaTA LBD + oxo-dodecanoyl-homoserine lactone<br />
**[[3ix4]], [[3ix8]], [[3jpu]], [[6d6a]], [[6d6b]], [[6d6c]], [[6d6d]], [[6d6l]], [[6d6m]], [[6d6n]], [[6d6o]], [[6d6p]] – PaTA LBD + benzoate derivative<br />
**[[3ix4]], [[3ix8]], [[3jpu]], [[6d6a]], [[6d6b]], [[6d6c]], [[6d6d]], [[6d6l]], [[6d6m]], [[6d6n]], [[6d6o]], [[6d6p]] – PaTA LBD + benzoate derivative<br />
**[[6mwl]] – PaTA + oxothiolan derivative<br />
**[[6mwl]] – PaTA + oxothiolan derivative<br />
Line 95: Line 96:
*Flagelar transcriptional activator
*Flagelar transcriptional activator
-
**[[1g8e]] – EcTA FLHD<br />
+
**[[1g8e]] – EcTA FlhD<br />
-
**[[2avu]] – EcTA FLHC+FLHD<br />
+
**[[2avu]] – EcTA FlhC+FlhD<br />
 +
**[[5hxg]] – StTA FlhD + STM1697 <br />
*TipA transcriptional activator
*TipA transcriptional activator
Line 162: Line 164:
**[[1al3]] – TA cofactor binding domain – ''Klebsiella aerogenes''<br />
**[[1al3]] – TA cofactor binding domain – ''Klebsiella aerogenes''<br />
**[[5z50]] – PaTA regulatory domain <br />
**[[5z50]] – PaTA regulatory domain <br />
-
**[[5z4y]] – PaTA NTD domain <br />
+
**[[5z4y]], [[5z4z]] – PaTA NTD domain <br />
*HlyU transcriptional activator
*HlyU transcriptional activator
-
**[[4k2e]], [[4ooi]] – TA - ''Vibrio cholerae''<br />
+
**[[4k2e]], [[4ooi]] – VcTA - ''Vibrio cholerae''<br />
-
**[[3jth]] – VvTA <br />
+
**[[3jth]] – VvTA - ''Vibrio vulnificus'' <br />
-
**[[5znx]] – TA + inhibitor - ''Vibrio vulnificus''<br />
+
**[[5znx]] – VvTA + inhibitor<br />
 +
 
 +
*ToxR TA
 +
 
 +
**[[6uue]], [[6utc]] – VvTA <br />
 +
 
 +
*LysR TA
 +
 
 +
**[[5x0o]] – VvTA <br />
 +
**[[5x0n]] – VvTA (mutant)<br />
 +
**[[3t1b]], [[3szp]] – VcTA <br />
 +
**[[6yz3]] – PaTA <br />
 +
**[[5z7h]] – SaTA <br />
 +
**[[4pzj]] – TA – ''Eggerthella lenta''<br />
 +
**[[3hhf]] – NmTA – ''Neisseria meningitidis'' <br />
 +
**[[3fzj]] – TA – ''Comamonas testosteroni''<br />
*Aft2 transcriptional activator
*Aft2 transcriptional activator
Line 176: Line 193:
*Cmpr transcriptional activator
*Cmpr transcriptional activator
-
**[[5z49]] – TA effector-binding domain + ribulose bisphosphate – Synechococcus elongatus<br />
+
**[[5z49]] – TA effector-binding domain + ribulose bisphosphate – ''Synechococcus elongatus''<br />
*Mga transcriptional activator
*Mga transcriptional activator
-
**[[5way]] – TA – Streptococcus pneumoniae<br />
+
**[[5way]] – SpTA – ''Streptococcus pneumoniae''<br />
*RhaR transcriptional activator
*RhaR transcriptional activator
-
**[[5u9e]], [[5u93]] – TA regulatory domain – Bacteria latreille<br />
+
**[[5u9e]], [[5u93]] – TA regulatory domain – ''Bacteria latreille''<br />
*Spt7 transcriptional activator
*Spt7 transcriptional activator
**[[6t9k]], [[6t9i]] – yTA in SAGA – Cryo EM<br />
**[[6t9k]], [[6t9i]] – yTA in SAGA – Cryo EM<br />
 +
 +
*Quorum-sensing TA
 +
 +
**[[5l07]] – YeTA – ''Yersinia enterocolitica''<br />
 +
**[[5l09]] – YeTA + THF derivative<br />
 +
 +
*MexT TA
 +
 +
**[[6l33]] – PaTA regulatory domain<br />
 +
 +
*ComR TA
 +
 +
**[[5juf]] – TA – ''Streptococcus thermophilus''<br />
 +
 +
*GabR TA
 +
 +
**[[5t4k]], [[5t4j]], [[5t4l]] – BsTA EBO domain + pyridine derivative<br />
 +
 +
*FasR TA
 +
 +
**[[6o6p]] – MtTA + DNA – ''Mycobacterium tuberculosis''<br />
 +
**[[6o6o]] – MtTA + myristic acid<br />
 +
 +
*PrpR TA
 +
 +
**[[6d2s]], [[6cyj]], [[6cz6]], [[6cyy]] – MtTA <br />
 +
 +
 +
*LrpC TA
 +
 +
**[[2cfx]] – BsTA <br />
 +
 +
*ModE TA
 +
 +
**[[1o7l]], [[1h9s]] – EcTA + Mo <br />
 +
**[[1b9m]], [[1b9n]] , [[1h9r]]– EcTA + Ni <br />
 +
 +
*RutR TA
 +
 +
**[[4x1e]] – EcTA <br />
 +
**[[4xk4]], [[4jyk]] – EcTA + uracil derivative<br />
 +
 +
*TetR family TA
 +
 +
**[[1z77]], [[2id6]], [[2iek]], [[1zkg]], [[4i76]], [[3ih2]], [[3ih3]], [[3ih4]] – TmTA – ''Thermotoga maritima''<br />
 +
**[[4i6z]] – TmTA + DNA<br />
 +
**[[1zk8]], [[2fq4]], [[4me9]] – BcTA – ''Bacillus cereus''<br />
 +
**[[3cwr]] – TA – ''Rhodspirillum rubrum''<br />
 +
**[[1z0x]] – EfTA – ''Enterococcus faecalis''<br />
 +
**[[3vuq]] – TtTA – ''Thermus thermophilus''<br />
 +
**[[3c2b]] – AfTA – ''Agrobacterium fabrum''<br />
 +
**[[2o7t]] – CgTA <br />
 +
**[[2g7s]] – AtTA <br />
 +
**[[5d19]] – MtTA <br />
 +
**[[3gzi]] – TA – ''Shewanella loihica''<br />
 +
**[[3dcf]] – TA – ''Thermobifida fusca''<br />
 +
**[[2qib]], [[2zcx]], [[6srm]] – TA – ''Streptomyces coelicolor''<br />
 +
**[[2hyt]] – TA – ''Pectobacterium atrosepticum''<br />
 +
**[[3cdl]] – PsTA – ''Pseudomonas syringae''<br />
 +
**[[3kkc]] – TA – ''Streptococcus agalactiae''<br />
 +
**[[3mvp]] – TA – ''Streptococcus mutans''<br />
 +
**[[3nnr]] – TA – ''Marinobacter aquaeolei''<br />
 +
**[[3on4]] – TA – ''Legionella pneumophila''<br />
 +
**[[2eh3]] – TA – ''Aquifex aeolicus''<br />
 +
**[[3f1b]] – RjTA – ''Rhodococcus jostii''<br />
 +
**[[3eup]] – TA – ''Cytophaga hutchinsonii''<br />
 +
**[[3egq]] – TA – ''Archaeoglobus fulgidus''<br />
 +
**[[4hku]] – TA – ''Listeria monocytogenes''<br />
 +
**[[3nrg]], [[3qbm]] – TA – ''Chlotoflexus aurantiacus''<br />
 +
**[[6g87]] – BdTA – ''Bradyrhizobium diazoefficiens''<br />
 +
**[[6g8h]] – BdTA + naringenin <br />
 +
**[[6g8g]] – BdTA + genistein <br />
 +
**[[6nsr]] – PaTA (mutant) + DNA<br />
 +
**[[4jkz]] – MsTA – ''Mycobacterium smegmatis''<br />
 +
**[[6el2]] – SacTA – ''Sulfolobus acidocaldarius''<br />
 +
**[[6en8]] – SacTA + DNA<br />
 +
 +
*GntR family TA
 +
 +
**[[3l5z]] – BcTA <br />
 +
**[[3ddv]] – EfTA <br />
 +
**[[3sxy]] – TmTA <br />
 +
**[[3c7j]] – PsTA <br />
 +
**[[2p19]] – CgTA <br />
 +
**[[3tqn]] – TA – ''Coxiella burnetii''<br />
 +
 +
*MarR family TA
 +
 +
**[[3boq]], [[3cjn]], [[3e6m]] – RpTA - ''Ruegeria pomeryi''<br />
 +
**[[3s2w]] – TA – ''Methanosarcina mazei'' <br />
 +
**[[2fbk]] – DrTA – ''Deinococcus radiodurans''<br />
 +
**[[5dd8]] – DrTA (mutant) <br />
 +
**[[2fa5]] – TA – ''Xanthomonas campestris''<br />
 +
**[[5aiq]] – NmTA <br />
 +
**[[5aip]] – NmTA + hydroxyphenylacetate <br />
 +
**[[5e1w]] – DmTA – ''Dihalococcoides mccartyi''<br />
 +
**[[5e1z]], [[5e1x]], [[5e20]] – DmTA + phenol derivative <br />
 +
**[[6c28]] – TA + coumaroyl-CoA – ''Rhodopseudomonas palustris'' <br />
 +
**[[3fm5]] – RjTA <br />
 +
**[[1z91]] – BsTA <br />
 +
 +
*MerR family TA
 +
 +
**[[3hh0]] – BcTA <br />
 +
**[[3gpv]] – BtTA <br />
 +
 +
*AsnC family TA
 +
 +
**[[3i4p]] – AfTA <br />
 +
 +
*AraC family TA
 +
 +
**[[3gra]] – PpTA – ''Pseudomonas putida''<br />
 +
**[[3cu5]] – TA – ''Lacnoclostridium phytofermentans''<br />
 +
**[[5chh]] – PaTA <br />
 +
 +
*LacI family TA
 +
 +
**[[3kjx]], [[3e3m]] – RpTA <br />
 +
**[[3jy6]] – TA - ''Lactobacillus brevis'' <br />
 +
**[[6chk]] – LcTA - ''Lactobacillus casei'' <br />
 +
**[[4rk5]], [[4rk4]] – LcTA + sugar <br />
 +
**[[4rk0]], [[4rk1]] – EfTA + ribose<br />
 +
**[[3h5t]] – CgTA <br />
 +
**[[3kke]] – MsTA <br />
 +
**[[4rkq]], [[4rkr]] – TA - ''Arthrobacter''<br />
 +
 +
*PadR family TA
 +
 +
**[[5zhv]], [[5zi8]], [[5zhc]] – MtTA <br />
 +
**[[5zqh]] – SpTA <br />
 +
**[[5x12]] – BsTA <br />
 +
**[[5y8t]] – BsTA + coumaric acid<br />
 +
 +
*TrmB TA
 +
 +
**[[2f5t]] – TA – Thermococcus litoralis<br />
 +
 +
*IclR TA
 +
 +
**[[1mkm]] – TmTA <br />
 +
 +
*BgaR TA
 +
 +
**[[6nwo]] – CpTA – ''Clostridium perfringens''<br />
 +
**[[6nx3]], [[6nwj]], [[6nwm]], [[6nwh]] – CpTA + pyranose derivative<br />
 +
 +
*SlyA TA
 +
 +
**[[1lj9]] – EfTA <br />
 +
**[[3qpt]] – StTA <br />
 +
**[[3q5f]] – StTA + DNA <br />
 +
**[[4aih]] – YpTA – Yersinia pseudotuberculosis<br />
 +
**[[4aij]], [[4aik]] – YpTA + DNA <br />
 +
 +
*BenM TA
 +
 +
**[[3k1n]] – AbTA – ''Acinetobacter baylyi''<br />
 +
**[[3k1p]] – AbTA (mutant)<br />
 +
**[[2f6g]], [[2f6p]], [[2f97]] – AbTA effector-binding domain 81-304<br />
 +
**[[3m1e]] – AbTA DBD 1-87<br />
 +
**[[4ihs]], [[4iht]] – AbTA effector-binding domain + DNA <br />
 +
**[[2f78]], [[2f7a]], [[2f7c]] – AbTA effector-binding domain + effector <br />
 +
**[[2h9b]] – EfTA (mutant)<br />
 +
 +
*CatM TA
 +
 +
**[[2f7b]], [[2h98]] – AbTA effector-binding domain <br />
 +
 +
*CouR TA
 +
 +
**[[5cyv]] – RjTA + coumaroyl-CoA – ''Rhodococcus jostii''<br />
 +
 +
*MgrA TA
 +
 +
**[[2bv6]] – SaTA – ''Staphylococcus aureus''<br />
 +
 +
*SarX TA
 +
 +
**[[5hs5]], [[5ywj]], [[6k8e]] – SaTA <br />
 +
 +
*QacR TA
 +
 +
**[[2gby]] – SaTA <br />
 +
**[[3br6]] – SaTA (mutant) + rhodamine<br />
 +
**[[3bqz]] – SaTA + malachite green<br />
 +
**[[3br1]], [[3br2]] – SaTA (mutant) + dequalinium<br />
 +
**[[2g0e]] – TA + drug – ''Staphylococcus haemolyticus''<br />
 +
 +
*AcrR TA
 +
 +
**[[2qop]] – EcTA <br />
 +
 +
*CueR TA
 +
 +
**[[1q07]], [[1q06]], [[1q05]] – EcTA <br />
 +
 +
*PurR TA
 +
 +
**[[3d8u]] – VpTA – ''Vibrio parahaemolyticus''<br />
 +
 +
*LuxR TA
 +
 +
**[[6wae]] – VvTA <br />
 +
**[[6wai]], [[6wah]], [[6wag]], [[6waf]] – VvTA (mutant)<br />
 +
 +
*LuxT TA
 +
 +
**[[3ljl]] – VpTA <br />
 +
 +
*ClgR TA
 +
 +
**[[5woq]] – MsTA <br />
 +
 +
*LmrR TA
 +
 +
**[[3f8b]], [[6i8n]] – LlTA – ''Lactococcus lactis''<br />
 +
**[[3f8c]], [[3f8f]] – LlTA + drug<br />
 +
**[[6vwe]], [[6do0]] – LlTA + Rh complex<br />
 +
**[[6r1l]] – LlTA + Cu + phenanthroline<br />
 +
 +
*MvfR TA
 +
 +
**[[6z17]] – PaTA <br />
 +
**[[6z5k]] – PaTA + inhibitor<br />
 +
 +
*HdfR TA
 +
 +
**[[6wn5]] – TA – ''Klebsiella pneumoniae''<br />
 +
 +
*McbR TA
 +
 +
**[[4p9f]] – EcTA <br />
 +
 +
*MetR TA
 +
 +
**[[5fo5]] – EcTA DBD<br />
 +
 +
*McbR TA
 +
 +
**[[3nxh]] – BsTA <br />
 +
 +
*CgmR TA
 +
 +
**[[2zoy]] – CgTA <br />
 +
**[[2zoz]] – CgTA + ethidium<br />
 +
 +
*AraR TA
 +
 +
**[[5bs6]] – TA – ''Bacterioides thetaiotaomicron''<br />
 +
 +
*CarH TA
 +
 +
**[[5c8d]] – TtTA + adnosylcobalamin<br />
 +
 +
*ZitR TA
 +
 +
**[[5yhy]], [[5yi0]], [[5yi1]] – LlTA (mutant)<br />
 +
 +
*LsrR TA
 +
 +
**[[4l4y]] – EcTA <br />
 +
**[[4l4z]], [[4l50]], [[4l51]], [[4l5i]], [[4l5j]] – EcTA + ligand<br />
 +
 +
*HTH-type TA
 +
 +
**[[2uxu]] – PpTA TtgR + naringenin<br />
 +
**[[2uxh]] – PpTA TtgR + quercetin<br />
 +
**[[2uxi]] – PpTA TtgR + phloretin<br />
 +
**[[6ugl]], [[6kju]] – VcTA + pyrazine derivative<br />
 +
**[[3hrm]], [[3hse]] – SaTA SarZ <br />
 +
**[[6r1p]] – MtTA EthR <br />
 +
**[[1ysq]] – EcTA YiaJ <br />
 +
**[[2gfn]] – RjTA Rha1 <br />
 +
**[[1i1g]] – TA LrpA – ''Pyrococcus furiosus''<br />
 +
**[[7cla]] – TA SkgA – ''Caulobacter vibrioides''<br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:24, 13 December 2020

3D Structures of transcriptional activator

Updated on 13-December-2020 - For a general description of the protein see Transcriptional activator


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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