Transferrin receptor

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</StructureSection>
</StructureSection>
==3D structures of transferrin receptor==
==3D structures of transferrin receptor==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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Domains – apical 197-378; ectodomain 121-760
[[1cx8]] – hTfR ectodomain – human<br />
[[1cx8]] – hTfR ectodomain – human<br />
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[[6y76]] - hTfR apical domain <br />
[[1de4]] - hTfR ectodomain + hemochromatosis protein + β-2-microglobulin<br />
[[1de4]] - hTfR ectodomain + hemochromatosis protein + β-2-microglobulin<br />
[[1suv]], [[6soy]], [[6soz]] - hTfR ectodomain + transferrin<br />
[[1suv]], [[6soy]], [[6soz]] - hTfR ectodomain + transferrin<br />
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[[6okd]] - hTfR ectodomain + TfR-binding cysteine-dense peptide<br />
[[6d03]], [[6d04]], [[6d05]] - hTfR ectodomain + transferrin – Cryo EM<br />
[[6d03]], [[6d04]], [[6d05]] - hTfR ectodomain + transferrin – Cryo EM<br />
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[[6gsr]], [[6h5i]] - hTfR ectodomain + ferritin heavy chain – Cryo EM<br />
[[6s9j]] - hTfR ectodomain + PRE-GP-C<br />
[[6s9j]] - hTfR ectodomain + PRE-GP-C<br />
[[3s9l]], [[3s9m]], [[3s9n]] - hTfR ectodomain + transferrin N-lobe<br />
[[3s9l]], [[3s9m]], [[3s9n]] - hTfR ectodomain + transferrin N-lobe<br />

Revision as of 08:33, 14 December 2020

Human transferrin receptor ectodomain dimer (grey and green) complex with transferrin N-lobe (pink and yellow) and C-lobe (cyan and magenta) and carbonate, 1suv

Drag the structure with the mouse to rotate

3D structures of transferrin receptor

Updated on 14-December-2020

Domains – apical 197-378; ectodomain 121-760

1cx8 – hTfR ectodomain – human
6y76 - hTfR apical domain
1de4 - hTfR ectodomain + hemochromatosis protein + β-2-microglobulin
1suv, 6soy, 6soz - hTfR ectodomain + transferrin
6okd - hTfR ectodomain + TfR-binding cysteine-dense peptide
6d03, 6d04, 6d05 - hTfR ectodomain + transferrin – Cryo EM
6gsr, 6h5i - hTfR ectodomain + ferritin heavy chain – Cryo EM
6s9j - hTfR ectodomain + PRE-GP-C
3s9l, 3s9m, 3s9n - hTfR ectodomain + transferrin N-lobe
2nsu - hTfR ectodomain in dog retrovirus – Cryo EM
3kas - hTfR ectodomain + Machupo virus GP1

References

  1. ↑ Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999 Apr;21(4):396-9. PMID:10192390 doi:http://dx.doi.org/10.1038/7727
  2. ↑ Cazzola M, Beguin Y, Bergamaschi G, Guarnone R, Cerani P, Barella S, Cao A, Galanello R. Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis. Br J Haematol. 1999 Sep;106(3):752-5. PMID:10468869

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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