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1dc0
From Proteopedia
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[[Image:1dc0.gif|left|200px]] | [[Image:1dc0.gif|left|200px]] | ||
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'''CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG''' | '''CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DC0 OCA]. | |
==Reference== | ==Reference== | ||
The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10688897 10688897] | The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10688897 10688897] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Dickerson, R E.]] | [[Category: Dickerson, R E.]] | ||
[[Category: Kopka, M L.]] | [[Category: Kopka, M L.]] | ||
[[Category: Ng, H. L.]] | [[Category: Ng, H. L.]] | ||
| - | [[Category: | + | [[Category: A-dna]] |
| - | [[Category: | + | [[Category: B-dna]] |
| - | [[Category: | + | [[Category: Intermediate]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:40:25 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:40, 2 May 2008
CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG
Overview
The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.
About this Structure
Full crystallographic information is available from OCA.
Reference
The structure of a stable intermediate in the A <--> B DNA helix transition., Ng HL, Kopka ML, Dickerson RE, Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2035-9. PMID:10688897 Page seeded by OCA on Fri May 2 13:40:25 2008
Categories: Dickerson, R E. | Kopka, M L. | Ng, H. L. | A-dna | B-dna | Intermediate
