Tyrosine kinase 3D structures
From Proteopedia
(Difference between revisions)
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**[[1srl]], [[1srm]] - cTK – NMR<br /> | **[[1srl]], [[1srm]] - cTK – NMR<br /> | ||
**[[3fj5]], [[4jz3]], [[4jz4]], [[6xvo]], [[6xvn]] - cTK<br /> | **[[3fj5]], [[4jz3]], [[4jz4]], [[6xvo]], [[6xvn]] - cTK<br /> | ||
| - | **[[4le9]], [[4oml]], [[4omm]], [[4omn]], [[4omo]], [[4omp]], [[4omq]], [[5i11]], [[4rtu]], [[4rtx]] - cTK (mutant) <br /> | + | **[[4le9]], [[4oml]], [[4omm]], [[4omn]], [[4omo]], [[4omp]], [[4omq]], [[5i11]], [[4rtu]], [[4rtx]], [[6xvm]] - cTK (mutant) <br /> |
**[[6xx3]], [[6xx2]], [[6xx5]], [[6xx4]], [[6xx5]], [[6xx2]] - cTK (mutant) + ion<br /> | **[[6xx3]], [[6xx2]], [[6xx5]], [[6xx4]], [[6xx5]], [[6xx2]] - cTK (mutant) + ion<br /> | ||
**[[4hxj]], [[1prl]], [[4qt7]], [[4rty]], [[4rtz]] - cTK + peptide<br /> | **[[4hxj]], [[1prl]], [[4qt7]], [[4rty]], [[4rtz]] - cTK + peptide<br /> | ||
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**[[1xbb]] - hSyk kinase domain + Gleevec<br /> | **[[1xbb]] - hSyk kinase domain + Gleevec<br /> | ||
**[[1xbc]] - hSyk kinase domain + staurosporine<br /> | **[[1xbc]] - hSyk kinase domain + staurosporine<br /> | ||
| - | **[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[4dfl]], [[4dfn]], [[3vf8]], [[3vf9]], [[3tub]], [[3tuc]], [[3tud]], [[4f4p]], [[4fyn]], [[4fyo]], [[4fz6]], [[4fz7]], [[4gfg]], [[4i0r]], [[4i0s]], [[4i0t]], [[4puz]], [[4pv0]], [[4rx7]], [[4rx8]], [[4rx9]], [[5lma]], [[5lmb]], [[5ghv]], [[4wnm]], [[4xg3]], [[4xg4]], [[4xg6]], [[4xg7]], [[4xg8]], [[4xg9]], [[4rss]], [[4yjv]], [[5c26]], [[5c27]], [[4yjo]], [[4yjp]], [[4yjq]], [[4yjr]], [[4yjs]], [[4yjt]], [[4yju]], [[5tr6]], [[5tt7]], [[5tiu]], [[5t68]], [[5y5t]], [[5y5u]], [[4gfg]], [[6hm6]], [[6hm7]], [[6vov]] - hSyk kinase domain + inhibitor<br /> | + | **[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[4dfl]], [[4dfn]], [[3vf8]], [[3vf9]], [[3tub]], [[3tuc]], [[3tud]], [[4f4p]], [[4fyn]], [[4fyo]], [[4fz6]], [[4fz7]], [[4gfg]], [[4i0r]], [[4i0s]], [[4i0t]], [[4puz]], [[4pv0]], [[4rx7]], [[4rx8]], [[4rx9]], [[5lma]], [[5lmb]], [[5ghv]], [[4wnm]], [[4xg3]], [[4xg4]], [[4xg6]], [[4xg7]], [[4xg8]], [[4xg9]], [[4rss]], [[4yjv]], [[5c26]], [[5c27]], [[4yjo]], [[4yjp]], [[4yjq]], [[4yjr]], [[4yjs]], [[4yjt]], [[4yju]], [[5tr6]], [[5tt7]], [[5tiu]], [[5t68]], [[5y5t]], [[5y5u]], [[4gfg]], [[6hm6]], [[6hm7]], [[6vov]], [[6ssb]] - hSyk kinase domain + inhibitor<br /> |
**[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br /> | **[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br /> | ||
**[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR /> | **[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR /> | ||
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**[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br /> | **[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br /> | ||
**[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br /> | **[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br /> | ||
| + | |||
| + | *'''Ptk7 tyrosine kinase''' | ||
| + | |||
| + | **[[6vg3]] - hTK Ptk7 kinase domain<br /> | ||
*'''PtkA tyrosine kinase''' | *'''PtkA tyrosine kinase''' | ||
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*'''Tyk2 tyrosine kinase''' (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170) | *'''Tyk2 tyrosine kinase''' (Domains: SH2+FERM 23-540; pseudokinase 541-880; kinase 880-1170) | ||
| - | **[[5f20]], [[5f1z]], [[6ova]] - hTK Tyk2 kinase domain + inhibitor<br /> | + | **[[5f20]], [[5f1z]], [[6ova]], [[6vns]], [[6vnv]], [[6vny]], [[6vnx]] - hTK Tyk2 kinase domain + inhibitor<br /> |
**[[3lxn]], [[3lxp]], [[3nyx]], [[3nz0]], [[4e1z]], [[4e20]], [[4gfo]], [[4gih]], [[4gii]], [[4gj2]], [[4gj3]], [[4py1]], [[5wal]], [[5wev]], [[6dbk]], [[6dbm]] - hTK Tyk2 kinase domain (mutant) + inhibitor<br /> | **[[3lxn]], [[3lxp]], [[3nyx]], [[3nz0]], [[4e1z]], [[4e20]], [[4gfo]], [[4gih]], [[4gii]], [[4gj2]], [[4gj3]], [[4py1]], [[5wal]], [[5wev]], [[6dbk]], [[6dbm]] - hTK Tyk2 kinase domain (mutant) + inhibitor<br /> | ||
**[[6aam]], [[6x8g]], [[6x8f]] - hTK Tyk2 kinase domain (mutant) + drug<br /> | **[[6aam]], [[6x8g]], [[6x8f]] - hTK Tyk2 kinase domain (mutant) + drug<br /> | ||
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**[[2ec8]] - hTK Kit extracellular domain<br /> | **[[2ec8]] - hTK Kit extracellular domain<br /> | ||
| - | **[[3g0e]], [[3g0f]] - hTK Kit kinase domain (mutant) + cancer drug<br /> | ||
**[[2e9w]] - hTK Kit extracellular domain + stem cell factor<br /> | **[[2e9w]] - hTK Kit extracellular domain + stem cell factor<br /> | ||
**[[1t45]], [[4pgz]] - hTK Kit kinase domain<br /> | **[[1t45]], [[4pgz]] - hTK Kit kinase domain<br /> | ||
**[[1t46]], [[4u0i]], [[6mob]], [[6kla]] - hTK Kit kinase domain + cancer drug<br /> | **[[1t46]], [[4u0i]], [[6mob]], [[6kla]] - hTK Kit kinase domain + cancer drug<br /> | ||
| - | **[[6gqj]], [[6gql]], [[6gqm]], [[6gqk]] - hTK Kit kinase domain (mutant) + cancer drug<br /> | + | **[[6gqj]], [[6gql]], [[6gqm]], [[6gqk]], [[3g0e]], [[3g0f]] - hTK Kit kinase domain (mutant) + cancer drug<br /> |
| - | **[[6itv]], [[6itt]] - hTK Kit kinase domain + inhibitor<br /> | + | **[[6itv]], [[6itt]], [[6xv9]], [[6xva]], [[6xvb]] - hTK Kit kinase domain + inhibitor<br /> |
**[[4hvs]], [[6hh1]] - hTK Kit kinase domain (mutant) + inhibitor<br /> | **[[4hvs]], [[6hh1]] - hTK Kit kinase domain (mutant) + inhibitor<br /> | ||
**[[2o26]] - hTK Kit residues 25-314 + Kit ligand<br /> | **[[2o26]] - hTK Kit residues 25-314 + Kit ligand<br /> | ||
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**[[3brb]] - hTK Mer kinase domain + ADP<br /> | **[[3brb]] - hTK Mer kinase domain + ADP<br /> | ||
**[[2p0c]] - hTK Mer kinase domain + ANP<br /> | **[[2p0c]] - hTK Mer kinase domain + ANP<br /> | ||
| - | **[[3bpr]], [[3tcp]], [[4m3q]], [[4mh7]], [[4mha]], [[5u6c]], [[5tc0]], [[5k0k]], [[5k0x]], [[5td2]], [[6mep]] - hTK Mer kinase domain + inhibitor<br /> | + | **[[3bpr]], [[3tcp]], [[4m3q]], [[4mh7]], [[4mha]], [[5u6c]], [[5tc0]], [[5k0k]], [[5k0x]], [[5td2]], [[6mep]], [[7cqe]] - hTK Mer kinase domain + inhibitor<br /> |
**[[7ab2]], [[7aax]], [[7aaz]] - hTK Mer kinase domain (mutant) + inhibitor<br /> | **[[7ab2]], [[7aax]], [[7aaz]] - hTK Mer kinase domain (mutant) + inhibitor<br /> | ||
**[[7ab1]] - hTK Mer kinase domain + anti-cancer drug<br /> | **[[7ab1]] - hTK Mer kinase domain + anti-cancer drug<br /> | ||
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**[[6nec]], [[6ne7]], [[7ju5]], [[7ju6]] - hTK Ret kinase domain + cancer drug<br /> | **[[6nec]], [[6ne7]], [[7ju5]], [[7ju6]] - hTK Ret kinase domain + cancer drug<br /> | ||
**[[4ux8]] - hTK Ret extracellular domain + GFR α 1<br /> | **[[4ux8]] - hTK Ret extracellular domain + GFR α 1<br /> | ||
| + | **[[6q2n]] - hTK Ret extracellular domain + GFR α-1 + GDNF - Cryo EM<br /> | ||
**[[6gl7]], [[6q2r]] - hTK Ret extracellular domain + GFR α 2 + neurturin - Cryo EM<br /> | **[[6gl7]], [[6q2r]] - hTK Ret extracellular domain + GFR α 2 + neurturin - Cryo EM<br /> | ||
**[[6q2s]] - hTK Ret extracellular domain + GFR α-3 + ARTN - Cryo EM<br /> | **[[6q2s]] - hTK Ret extracellular domain + GFR α-3 + ARTN - Cryo EM<br /> | ||
Revision as of 11:30, 28 December 2020
3D structures of tyrosine kinase
Updated on 28-December-2020 - For a general description of the protein see Tyrosine kinase
