1vdd

From Proteopedia

(Difference between revisions)

Revision as of 07:35, 30 December 2020

Crystal structure of recombinational repair protein RecR

Structural highlights

1vdd is a 4 chain structure with sequence from "micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Gene:	recR ("Micrococcus radiodurans" Raj et al. 1960)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[RECR_DEIRA] May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

RecR, together with RecF and RecO, facilitates RecA loading in the RecF pathway of homologous recombinational DNA repair in procaryotes. The human Rad52 protein is a functional counterpart of RecFOR. We present here the crystal structure of RecR from Deinococcus radiodurans (DR RecR). A monomer of DR RecR has a two-domain structure: the N-terminal domain with a helix-hairpin-helix (HhH) motif and the C-terminal domain with a Cys4 zinc-finger motif, a Toprim domain and a Walker B motif. Four such monomers form a ring-shaped tetramer of 222 symmetry with a central hole of 30-35 angstroms diameter. In the crystal, two tetramers are concatenated, implying that the RecR tetramer is capable of opening and closing. We also show that DR RecR binds to both dsDNA and ssDNA, and that its HhH motif is essential for DNA binding.

Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair.,Lee BI, Kim KH, Park SJ, Eom SH, Song HK, Suh SW EMBO J. 2004 May 19;23(10):2029-38. Epub 2004 Apr 29. PMID:15116069^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lee BI, Kim KH, Park SJ, Eom SH, Song HK, Suh SW. Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair. EMBO J. 2004 May 19;23(10):2029-38. Epub 2004 Apr 29. PMID:15116069 doi:10.1038/sj.emboj.7600222

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vdd"

@@ Line 1: / Line 1: @@
 ==Crystal structure of recombinational repair protein RecR==
-<StructureSection load='1vdd' size='340' side='right' caption='[[1vdd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='1vdd' size='340' side='right'caption='[[1vdd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1vdd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VDD FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1vdd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1VDD FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">recR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1299 "Micrococcus radiodurans" Raj et al. 1960])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdd OCA], [http://pdbe.org/1vdd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vdd RCSB], [http://www.ebi.ac.uk/pdbsum/1vdd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdd ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1vdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdd OCA], [http://pdbe.org/1vdd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vdd RCSB], [http://www.ebi.ac.uk/pdbsum/1vdd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdd ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 34: / Line 34: @@
 </StructureSection>
 [[Category: Micrococcus radiodurans raj et al. 1960]]
+[[Category: Large Structures]]
 [[Category: Kim, K H]]
 [[Category: Lee, B I]]

1vdd

From Proteopedia

Revision as of 07:35, 30 December 2020

Crystal structure of recombinational repair protein RecR

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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