Undecaprenyl pyrophosphate synthase
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
| - | '''Undecaprenyl pyrophosphate synthase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors. | + | '''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transferase''' or '''poly-cys-prenyltransferase''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors. |
== Relevance == | == Relevance == | ||
| Line 26: | Line 26: | ||
**[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br /> | **[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br /> | ||
**[[5xk3]] – StUPP – ''Streptmyces''<br /> | **[[5xk3]] – StUPP – ''Streptmyces''<br /> | ||
| + | **[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br /> | ||
*Undecaprenyl pyrophosphate synthase complexes | *Undecaprenyl pyrophosphate synthase complexes | ||
| Line 37: | Line 38: | ||
**[[1x09]] – EcUPP (mutant) + Mg + IPP<br /> | **[[1x09]] – EcUPP (mutant) + Mg + IPP<br /> | ||
**[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br /> | **[[2e98]], [[2e99]], [[2e9a]], [[2e9c]], [[2e9d]], [[3th8]], [[3sgt]], [[3sgv]], [[3sgx]], [[3sh0]], [[4h2j]], [[4h2m]], [[4h2o]], [[4h38]], [[4h3c]], [[4h3a]], [[4h8e]], [[3wyj]] – EcUPP + bisphosphonate<br /> | ||
| - | **[[5cqj]] – EcUPP + inhibitor <br /> | + | **[[5cqj]], [[5zhe]] – EcUPP + inhibitor <br /> |
**[[5kh4]] – SpUPP + FPP <br /> | **[[5kh4]] – SpUPP + FPP <br /> | ||
**[[5kh5]] – SpUPP + inhibitor <br /> | **[[5kh5]] – SpUPP + inhibitor <br /> | ||
| Line 48: | Line 49: | ||
**[[5xk7]] – StUPP + DMAPP <br /> | **[[5xk7]] – StUPP + DMAPP <br /> | ||
**[[5xk9]] – StUPP + GSPP + DMAPP <br /> | **[[5xk9]] – StUPP + GSPP + DMAPP <br /> | ||
| - | **[[6szg]], [[6szh]] - | + | **[[6szg]], [[6szh]] - AbUPP + inhibitor<br /> |
}} | }} | ||
Revision as of 06:58, 7 January 2021
| |||||||||||
3D structures of undecaprenyl pyrophosphate synthase
Updated on 07-January-2021
References
- ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
- ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
- ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
