Undecaprenyl pyrophosphate synthase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl | + | '''Undecaprenyl pyrophosphate synthase''' or '''isoprenyl transfe rase''' or '''poly-cis-prenyltransferase''' or '''ditrans,polycis-undecaprenyl pyrophosphate synthase ((2E,6E) farnesyl diphosphate specific)''' (UPP) catalyzes the consecutive condensation of farnesyl pyrophosphate (FPP) with 8 molecules of isopentenyl pyrophosphate (IPP) to produce undecaprenyl pyrophosphate. Undecaprenyl pyrophosphate serves as a lipid carrier for peptidoglycan synthesis of bacterial cell wall<ref>PMID:15788389</ref>. Bisphosphonate drugs are UPP inhibitors. |
== Relevance == | == Relevance == | ||
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**[[5xk3]] – StUPP – ''Streptmyces''<br /> | **[[5xk3]] – StUPP – ''Streptmyces''<br /> | ||
**[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br /> | **[[6acs]] - AbUPP - ''Acinetobacter baumannii''<br /> | ||
| + | **[[6loi]] - AbUPP - ''Enterococcus faecalis''<br /> | ||
*Undecaprenyl pyrophosphate synthase complexes | *Undecaprenyl pyrophosphate synthase complexes | ||
Revision as of 08:07, 7 January 2021
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3D structures of undecaprenyl pyrophosphate synthase
Updated on 07-January-2021
References
- ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
- ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
- ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
