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Sandbox Reserved 1644

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{{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
{{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
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==Your Heading Here (maybe something like 'Structure')==
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==2x36 - Structure of the proteolytic domain of the Human Mitochondrial Lon protease==
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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==2x36 - Structure of the proteolytic domain of the Human Mitochondrial Lon protease==
 
'''2x36''' is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This domain belongs to the [https://en.wikipedia.org/wiki/Lon_protease_family] Lon protease family.
'''2x36''' is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This domain belongs to the [https://en.wikipedia.org/wiki/Lon_protease_family] Lon protease family.
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Mitochondrial Lon protease is an '''ATP-dependent serine protease''' involved in the selective degradation of abnormal proteins. [https://en.wikipedia.org/wiki/LONP1 LONP1] situated on chromosome 19 is the nuclear gene encoding mitochondrial Lon protein. The single species of [https://en.wikipedia.org/wiki/Messenger_RNA mRNA] of this protein is found in the mitochondrial matrix. This protein from human tissues has a molecular mass of 100 [https://en.wikipedia.org/wiki/Dalton_(unit) kDA].
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[https://en.wikipedia.org/wiki/Mitochondrion Mitochondrial] Lon [https://en.wikipedia.org/wiki/Protease protease] is an '''ATP-dependent serine protease''' involved in the selective degradation of abnormal proteins. [https://en.wikipedia.org/wiki/LONP1 LONP1] situated on chromosome 19 is the nuclear gene encoding mitochondrial Lon protein. The single species of [https://en.wikipedia.org/wiki/Messenger_RNA mRNA] of this protein is found in the mitochondrial matrix. This protein from human tissues has a molecular mass of 100 [https://en.wikipedia.org/wiki/Dalton_(unit) kDA].
== Function ==
== Function ==
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The mitochondrial Lon protease is an important regulator of mitochondrial [https://en.wikipedia.org/wiki/Metabolism metabolism] including the maintenance and repair of mitochondrial [https://en.wikipedia.org/wiki/DNA DNA], the homeostasis of mitochondria, and by regulating some regulatory proteins which have a short life or damaged proteins.
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Lon protease has three main roles. It has a [https://en.wikipedia.org/wiki/Proteolysis proteolytic] digestion of oxidized proteins
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== General structure ==
== General structure ==

Revision as of 16:14, 12 January 2021

This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

2x36 - Structure of the proteolytic domain of the Human Mitochondrial Lon protease

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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