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Function

NOTCH family : The NOTCH family encodes transmembrane receptor proteins that are involved in cell fate determination during development. In the drosophila adult midgut, intestinal stem cells produce two types of daughter cells, the nutrient-absorbing enterocytes (ECs) and secretory enteroendocrine (ee) cells. Notch signalling between intestinal stem cells and their daughter cells guides cell specification. ISCs with elevated levels of the Notch Delta ligand more primarily activate the Notch signalling pathway in daughter cells and cause them to become ECs. However, ISCs having low levels of Notch Delta ligand direct daughter cells to become ee cells. The NOTCH gene family in humans has a link with the Drosophila Notch gene. Members of the NOTCH gene family encode transmembrane receptor proteins that are useful to determine the cell fate during development.

Disease

Relevance

Structural highlights

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