Ionotropic receptors

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*[[Molecular Playground/Glutamate Receptor|AMPA glutamate receptor]] by [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
*[[Molecular Playground/Glutamate Receptor|AMPA glutamate receptor]] by [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst and on display at the [http://www.molecularplayground.org/ Molecular Playground].
*[[Glutamate receptor (GluA2)]]
*[[Glutamate receptor (GluA2)]]
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=PIP<sub>2</sub>-gated channels=
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Phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>) binds to and directly activates inwardly rectifying potassium channels.
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'''Inward rectifier KCh:'''
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**[[6c3p]], [[6c3o]] - hIRK 11 + SUR1 + ATP + ADP – Cryo EM<br />
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**[[6baa]] - hIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
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**[[3ukm]] – hIRK TWIK-1<br />
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**[[3um7]] – hIRK TRAAK<br />
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**[[4ruf]], [[4rue]] - hIRK TRAAK (mutant)<br />
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**[[4wfh]], [[4wfg]], [[4wfe]], [[4wff]] - hIRK TRAAK + antibody<br />
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**[[4i9w]] - hIRK TRAAK (mutant) + antibody<br />
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**[[6pz9]], [[6pza]], [[5twv]] - rIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
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**[[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br />
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**[[2xky]] - mIRK 2 cytoplasmic domain - EM<br />
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**[[2gix]], [[3vsq]] - mIRK 2 cytoplasmic domain (mutant)<br />
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**[[2e4f]] - mIRK 2 fragment<br />
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**[[1n9p]], [[1u4e]] - mIRK 1 cytoplasmic domain<br />
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**[[3k6n]] - mIRK 1 cytoplasmic domain (mutant)<br />
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**[[5um4]] - mIRK 3.1 (mutant)<br />
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**[[3at8]], [[3at9]], [[3ata]], [[3atb]], [[3atd]], [[3ate]], [[3atf]], [[3auw]], [[3syo]] - mIRK 3.2<br />
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**[[6xis]], [[6xit]] - mIRK 3.2 – Cryo EM<br />
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**[[3syc]], [[3syp]] - mIRK 3.2 (mutant) <br />
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**[[3sya]] - mIRK 3.2 + PIP2<br />
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**[[3syq]] - mIRK 3.2 (mutant) + PIP2<br />
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**[[4kfm]] - mIRK 3.2 + guanine nucleotide-biding protein<br />
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**[[5wua]], [[5twv]] - mIRK 11 + SUR1 - Cryo EM<br />
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**[[5ywc]], [[5ywb]] - mIRK 11 + SUR1 + ADP – Cryo EM<br />
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**[[5ywa]], [[5yw9]], [[5yw8]] - mIRK 11 + SUR1 + ATP – Cryo EM<br />
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**[[5ykg]], [[5ykf]], [[5yke]], [[6jb1]] - mIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
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**[[6m85]] – cIRK 2.2<br />
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**[[3spj]], [[6m86]] – cIRK 2.2 (mutant)<br />
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**[[3spc]] – cIRK 2.2 + DGPP <br />
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**[[3spg]], [[3sph]], [[5kum]], [[5kuk]], [[6m84]] – cIRK 2.2 (mutant) + PIP2<br />
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**[[3spi]] – cIRK 2.2 + PIP2<br />
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**[[7cal]] - AtIRK KAT1 – Cryo EM<br />
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**[[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]], [[6o9u]] - MmIRK KIRBAC3.1<br />
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**[[4lp8]], [[6o9t]], [[6o9v]] - MmIRK KIRBAC3.1 (mutant) <br />
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**[[3zrs]] – MmIRK 10<br />
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**[[1p7b]] - BpIRK C-terminal<br />
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</StructureSection>
</StructureSection>
==References==
==References==
<references/>
<references/>

Revision as of 19:03, 26 January 2021

The rat glycosylated glutamate receptor in complex with a competitive antagonist (3kg2)

Drag the structure with the mouse to rotate

References

  1. ↑ De Rienzo F, Moura Barbosa AJ, Perez MA, Fernandes PA, Ramos MJ, Menziani MC. The extracellular subunit interface of the 5-HT(3) receptors: a computational alanine scanning mutagenesis study. J Biomol Struct Dyn. 2012 Jul;30(3):280-98. Epub 2012 Jun 12. PMID:22694192 doi:10.1080/07391102.2012.680029

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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