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2cr7
From Proteopedia
(Difference between revisions)
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==Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B== | ==Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B== | ||
| - | <StructureSection load='2cr7' size='340' side='right' caption='[[2cr7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2cr7' size='340' side='right'caption='[[2cr7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cr7]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR7 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIN3B ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIN3B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr7 OCA], [https://pdbe.org/2cr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr7 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE]] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Hayashi, F]] | [[Category: Hayashi, F]] | ||
Revision as of 11:47, 3 February 2021
Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B
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