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2crn
From Proteopedia
(Difference between revisions)
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==Solution structure of the UBA domain of human UBASH3A protein== | ==Solution structure of the UBA domain of human UBASH3A protein== | ||
| - | <StructureSection load='2crn' size='340' side='right' caption='[[2crn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2crn' size='340' side='right'caption='[[2crn]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2crn]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2crn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRN FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBASH3A ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBASH3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2crn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2crn OCA], [https://pdbe.org/2crn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2crn RCSB], [https://www.ebi.ac.uk/pdbsum/2crn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2crn ProSAT], [https://www.topsan.org/Proteins/RSGI/2crn TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/UBS3A_HUMAN UBS3A_HUMAN]] Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.<ref>PMID:15159412</ref> <ref>PMID:17382318</ref> <ref>PMID:18189269</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hayashi, F]] | [[Category: Hayashi, F]] | ||
[[Category: Izumi, K]] | [[Category: Izumi, K]] | ||
Revision as of 11:48, 3 February 2021
Solution structure of the UBA domain of human UBASH3A protein
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