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2cyx
From Proteopedia
(Difference between revisions)
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==Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)== | ==Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)== | ||
| - | <StructureSection load='2cyx' size='340' side='right' caption='[[2cyx]], [[Resolution|resolution]] 2.56Å' scene=''> | + | <StructureSection load='2cyx' size='340' side='right'caption='[[2cyx]], [[Resolution|resolution]] 2.56Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cyx]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cyx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CYX FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBE2G2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UBE2G2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyx OCA], [https://pdbe.org/2cyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cyx RCSB], [https://www.ebi.ac.uk/pdbsum/2cyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cyx ProSAT], [https://www.topsan.org/Proteins/RSGI/2cyx TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/UB2G2_HUMAN UB2G2_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).<ref>PMID:20061386</ref> <ref>PMID:22607976</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Ubiquitin--protein ligase]] | [[Category: Ubiquitin--protein ligase]] | ||
[[Category: Arai, R]] | [[Category: Arai, R]] | ||
Revision as of 11:52, 3 February 2021
Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)
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