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2e19

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==Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8==
==Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8==
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<StructureSection load='2e19' size='340' side='right' caption='[[2e19]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2e19' size='340' side='right'caption='[[2e19]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2e19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E19 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2e19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E19 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TCF8, AREB6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TCF8, AREB6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e19 OCA], [http://pdbe.org/2e19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e19 RCSB], [http://www.ebi.ac.uk/pdbsum/2e19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2e19 ProSAT], [http://www.topsan.org/Proteins/RSGI/2e19 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e19 OCA], [https://pdbe.org/2e19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e19 RCSB], [https://www.ebi.ac.uk/pdbsum/2e19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e19 ProSAT], [https://www.topsan.org/Proteins/RSGI/2e19 TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ZEB1_HUMAN ZEB1_HUMAN]] Fuchs endothelial corneal dystrophy;Posterior polymorphous corneal dystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[[https://www.uniprot.org/uniprot/ZEB1_HUMAN ZEB1_HUMAN]] Fuchs endothelial corneal dystrophy;Posterior polymorphous corneal dystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ZEB1_HUMAN ZEB1_HUMAN]] Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.<ref>PMID:19935649</ref> <ref>PMID:20175752</ref> <ref>PMID:20418909</ref>
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[[https://www.uniprot.org/uniprot/ZEB1_HUMAN ZEB1_HUMAN]] Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.<ref>PMID:19935649</ref> <ref>PMID:20175752</ref> <ref>PMID:20418909</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Harada, T]]
[[Category: Harada, T]]
[[Category: Kigawa, T]]
[[Category: Kigawa, T]]

Revision as of 11:44, 10 February 2021

Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8

PDB ID 2e19

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