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2e9h
From Proteopedia
(Difference between revisions)
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==Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5== | ==Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5== | ||
| - | <StructureSection load='2e9h' size='340' side='right' caption='[[2e9h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2e9h' size='340' side='right'caption='[[2e9h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e9h]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2e9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E9H FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EIF5 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EIF5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e9h OCA], [https://pdbe.org/2e9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e9h RCSB], [https://www.ebi.ac.uk/pdbsum/2e9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e9h ProSAT], [https://www.topsan.org/Proteins/RSGI/2e9h TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IF5_HUMAN IF5_HUMAN]] Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Eukaryotic initiation factor|Eukaryotic initiation factor]] | + | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Harada, T]] | [[Category: Harada, T]] | ||
[[Category: Kigawa, T]] | [[Category: Kigawa, T]] | ||
Revision as of 11:53, 10 February 2021
Solution structure of the eIF-5_eIF-2B domain from human Eukaryotic translation initiation factor 5
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Categories: Human | Large Structures | Harada, T | Kigawa, T | Koshiba, S | Structural genomic | Tochio, N | Tomizawa, T | Watanabe, S | Yokoyama, S | C4 type zinc finger | National project on protein structural and functional analyse | Nppsfa | Rsgi | Translation | Translation initiation factor | Zinc binding
