1dp2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1dp2.jpg|left|200px]]
[[Image:1dp2.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1dp2 |SIZE=350|CAPTION= <scene name='initialview01'>1dp2</scene>, resolution 2.01&Aring;
+
The line below this paragraph, containing "STRUCTURE_1dp2", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>, <scene name='pdbligand=LPA:LIPOIC+ACID'>LPA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiosulfate_sulfurtransferase Thiosulfate sulfurtransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.1 2.8.1.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1dp2| PDB=1dp2 | SCENE= }}
-
|RELATEDENTRY=[[2ora|2ORA]], [[1orb|1ORB]], [[1rhd|1RHD]], [[1boi|1BOI]], [[1boh|1BOH]], [[1rhs|1RHS]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dp2 OCA], [http://www.ebi.ac.uk/pdbsum/1dp2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dp2 RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RHODANESE AND LIPOATE'''
'''CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RHODANESE AND LIPOATE'''
Line 28: Line 25:
[[Category: Cianci, M.]]
[[Category: Cianci, M.]]
[[Category: Zanotti, G.]]
[[Category: Zanotti, G.]]
-
[[Category: liopate]]
+
[[Category: Liopate]]
-
[[Category: rhodanese]]
+
[[Category: Rhodanese]]
-
[[Category: sulfurtransferase]]
+
[[Category: Sulfurtransferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:06:09 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:45:51 2008''
+

Revision as of 11:06, 2 May 2008

Image:1dp2.jpg

Template:STRUCTURE 1dp2

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN RHODANESE AND LIPOATE


Overview

Dihydrolipoate is an acceptor of the rhodanese-bound sulfane sulfur atom, as shown by analysis of the elementary steps of the reaction catalyzed by rhodanese. The crystal structure of sulfur-substituted rhodanese complexed with the non-reactive oxidized form of lipoate has revealed that the compound is bound at the enzyme active site, with the dithiolane ring buried in the interior of the cavity and the carboxylic end pointing towards the solvent. One of the sulfur atoms of the ligand in the unproductive complex is relatively close to the sulfane sulfur bound to Cys-247, the sulfur that is transferred during the catalytic reaction. This mode of binding of lipoate is likely to mimic that of dihydrolipoate. The results presented here support the possible role of dihydrolipoate as sulfur-acceptor substrate of rhodanese in an enzymatic reaction that might serve to provide iron-sulfur proteins with inorganic sulfide.

About this Structure

1DP2 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Specific interaction of lipoate at the active site of rhodanese., Cianci M, Gliubich F, Zanotti G, Berni R, Biochim Biophys Acta. 2000 Aug 31;1481(1):103-8. PMID:11004580 Page seeded by OCA on Fri May 2 14:06:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dp2"
Personal tools