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Sandbox GGC13
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| - | + | ==1BVN: Pig Pancreatic Alpha-Amylase== | |
| - | <StructureSection load=' | + | <StructureSection load='1BVN' size='340' side='right' caption='Caption for this structure' scene=''> |
| - | This is | + | This protein that is being explained is commonly known as the Pig Pancreatic Alpha-Amylase that is in complex with the proteinaceous inhibitor tendamistat. |
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== Function == | == Function == | ||
| - | + | The function of the protein that is listed on the uniport website states that the two forms of this enzyme show that it is very similar with its activities, molecular masses, and compositions to each other but show differences in their isoelectric points only. There is no evidence of that the two variants in the cDNA library on PubMed: 10082956. The two forms, isoform I (PPAI) and isoform II (PPAII), are most likely the same protein. There is endohydrolysis of (1-4)-alpha-D-glucosidic linkages in the polysaccharides that contain three or more (1-4)-alpha-linked-D-glucose units. | |
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== Disease == | == Disease == | ||
| + | This protein is not associated with any diseases at this time. | ||
== Relevance == | == Relevance == | ||
| + | ((need to research relevance of the protein)) | ||
| + | ==Structure== | ||
| + | There is the processing of the protein in the single peptide with the location of 1-15 and the chain with the location of 16-511. The modifications of the protein can be found in the modified residue (16), disulfide bonds (43-101, 85-130, 156-175, 393-399,465-477), and glycosylation (427). There is no active site on this protein. | ||
| + | The protein is located in the extracellular region of the cell or secreted. | ||
== Structural highlights == | == Structural highlights == | ||
| - | Lactate dehydrogenase is a tetramer protein which can form five different isoenzymes. Lactate dehydrogenase subunits exist primarily in two isoforms: M and H, which differ in a single residue. The M subunit contains an alanine while the H subunit contains a glutamine. The combination of subunits defines which isoenzyme is formed and indicates where the enzyme will be present in the body. Lactate dehydrogenase A is composed of four M subunits. The subunits can adopt two conformations, open and closed, which determine the subunits activity. | ||
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| - | <scene name='78/781197/Oxamate/1'>Close up interactions between the substrate binding pocket and the inhibitor, oxamate. The substrate active site to which oxamate is bound is in the closed conformation.</scene> | ||
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| - | <scene name='78/781197/Nadh/2'>Close up interactions between the NADH and adenine binding pockets and the cofactor, NADH.</scene> | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Current revision
1BVN: Pig Pancreatic Alpha-Amylase
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