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Cys-loop receptors

Cationic cys-loop receptors

Serotonin type-3 receptor (5-HT3-R)

• 5-hydroxytryptamine receptor#Structural highlights/Specific Function of 5-HT3
• The extracellular subunit interface of the 5-HT3 receptors: a computational alanine scanning mutagenesis study^[1]
• 5-hydroxytryptamine receptor#5-HT3 receptor antagonists

5-HT3A receptor

Nicotinic acetylcholine receptors

• Nicotinic Acetylcholine Receptors in general
• Alpha-bungarotoxin is a nicotinic cholinergic antagonist that is found within the venom of Bungarus multicinctus, a South-asian snake belonging to a group commonly known as kraits.
• Binding site of AChR
• Acetylcholine Receptor and its Reaction to Cobra Venom

Anionic cys-loop receptors

GABA_A receptors

• 4cof – hGABAA subunit β-3 - human
  
• 6i53, 6hup, 6huo, 6huk, 6huj, 6hug – hGABAA subunits β-3 + α-1+γ-2 + megabody – Cryo EM
  
• 6d6u, 6d6t – hGABAA subunits β-3 +α-1+γ-2 + antibody + GABA + flumazenil – Cryo EM
  
• 6a96 – hGABAA subunits β-3 +α-5 + nanobody + GABA – Cryo EM
  
• 6hsn – rGABAA subunit α-3 + gephyrin + ADP - rat
  
• 6dw1, 6dw0 – rGABAA subunits β-1 +α-1+γ-2 + GABA – Cryo EM
  

Ionotropic Glutamate Receptors

AMPA glutamate receptor

• AMPA glutamate receptor by University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
• Glutamate receptor (GluA2)

ATP-gated P2X receptor cation channel family

Examples: 3h9v, 3i5d

PIP₂-gated channels

Phosphatidylinositol 4,5-bisphosphate (PIP₂) binds to and directly activates inwardly rectifying potassium channels. Inward rectifier KCh:

• • 6c3p, 6c3o - hIRK 11 + SUR1 + ATP + ADP – Cryo EM
    
  • 6baa - hIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM
    
  • 3ukm – hIRK TWIK-1
    
  • 3um7 – hIRK TRAAK
    
  • 4ruf, 4rue - hIRK TRAAK (mutant)
    
  • 4wfh, 4wfg, 4wfe, 4wff - hIRK TRAAK + antibody
    
  • 4i9w - hIRK TRAAK (mutant) + antibody
    
  • 6pz9, 6pza, 5twv - rIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM
    
  • 1u4f,3agw - mIRK 2 cytoplasmic domain
    
  • 2xky - mIRK 2 cytoplasmic domain - EM
    
  • 2gix, 3vsq - mIRK 2 cytoplasmic domain (mutant)
    
  • 2e4f - mIRK 2 fragment
    
  • 1n9p, 1u4e - mIRK 1 cytoplasmic domain
    
  • 3k6n - mIRK 1 cytoplasmic domain (mutant)
    
  • 5um4 - mIRK 3.1 (mutant)
    
  • 3at8, 3at9, 3ata, 3atb, 3atd, 3ate, 3atf, 3auw, 3syo - mIRK 3.2
    
  • 6xis, 6xit - mIRK 3.2 – Cryo EM
    
  • 3syc, 3syp - mIRK 3.2 (mutant)
    
  • 3sya - mIRK 3.2 + PIP2
    
  • 3syq - mIRK 3.2 (mutant) + PIP2
    
  • 4kfm - mIRK 3.2 + guanine nucleotide-biding protein
    
  • 5wua, 5twv - mIRK 11 + SUR1 - Cryo EM
    
  • 5ywc, 5ywb - mIRK 11 + SUR1 + ADP – Cryo EM
    
  • 5ywa, 5yw9, 5yw8 - mIRK 11 + SUR1 + ATP – Cryo EM
    
  • 5ykg, 5ykf, 5yke, 6jb1 - mIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM
    
  • 6m85 – cIRK 2.2
    
  • 3spj, 6m86 – cIRK 2.2 (mutant)
    
  • 3spc – cIRK 2.2 + DGPP
    
  • 3spg, 3sph, 5kum, 5kuk, 6m84 – cIRK 2.2 (mutant) + PIP2
    
  • 3spi – cIRK 2.2 + PIP2
    
  • 7cal - AtIRK KAT1 – Cryo EM
    
  • 1xl4, 1xl6, 2wlk, 2x6a, 2x6b, 2x6c, 6o9u - MmIRK KIRBAC3.1
    
  • 4lp8, 6o9t, 6o9v - MmIRK KIRBAC3.1 (mutant)
    
  • 3zrs – MmIRK 10
    
  • 1p7b - BpIRK C-terminal