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2f6q
From Proteopedia
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| - | [[Image:2f6q.png|left|200px]] | ||
| - | + | ==The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)== | |
| - | + | <StructureSection load='2f6q' size='340' side='right'caption='[[2f6q]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2f6q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F6Q FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | == | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[2f6q]] is a 3 chain structure with sequence from [ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PECI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dodecenoyl-CoA_isomerase Dodecenoyl-CoA isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.8 5.3.3.8] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6q OCA], [https://pdbe.org/2f6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f6q RCSB], [https://www.ebi.ac.uk/pdbsum/2f6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f6q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ECI2_HUMAN ECI2_HUMAN]] Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/2f6q_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f6q ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Dodecenoyl-CoA isomerase]] | [[Category: Dodecenoyl-CoA isomerase]] | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Arrowsmith, C | + | [[Category: Large Structures]] |
| - | [[Category: Berridge, G | + | [[Category: Arrowsmith, C]] |
| - | [[Category: Delft, F von | + | [[Category: Berridge, G]] |
| - | [[Category: Edwards, A | + | [[Category: Delft, F von]] |
| - | [[Category: Gileadi, O | + | [[Category: Edwards, A]] |
| - | [[Category: Guo, K | + | [[Category: Gileadi, O]] |
| - | [[Category: Lukacik, P | + | [[Category: Guo, K]] |
| - | [[Category: Oppermann, U | + | [[Category: Lukacik, P]] |
| - | [[Category: | + | [[Category: Oppermann, U]] |
| - | [[Category: Shafqat, N | + | [[Category: Structural genomic]] |
| - | [[Category: Smee, C | + | [[Category: Shafqat, N]] |
| - | [[Category: Sundstrom, M | + | [[Category: Smee, C]] |
| - | [[Category: Turnbull, A | + | [[Category: Sundstrom, M]] |
| - | [[Category: Weigelt, J | + | [[Category: Turnbull, A]] |
| + | [[Category: Weigelt, J]] | ||
[[Category: Enoyl coa isomerase]] | [[Category: Enoyl coa isomerase]] | ||
[[Category: Fatty acid metabolism]] | [[Category: Fatty acid metabolism]] | ||
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[[Category: Peroxisome]] | [[Category: Peroxisome]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Current revision
The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)
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Categories: Dodecenoyl-CoA isomerase | Human | Large Structures | Arrowsmith, C | Berridge, G | Delft, F von | Edwards, A | Gileadi, O | Guo, K | Lukacik, P | Oppermann, U | Structural genomic | Shafqat, N | Smee, C | Sundstrom, M | Turnbull, A | Weigelt, J | Enoyl coa isomerase | Fatty acid metabolism | Isomerase | Peroxisome | Sgc
