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2f6q

From Proteopedia

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[[Image:2f6q.gif|left|200px]]
 
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==The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)==
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The line below this paragraph, containing "STRUCTURE_2f6q", creates the "Structure Box" on the page.
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<StructureSection load='2f6q' size='340' side='right'caption='[[2f6q]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f6q]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F6Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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-->
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2f6q| PDB=2f6q | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PECI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dodecenoyl-CoA_isomerase Dodecenoyl-CoA isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.8 5.3.3.8] </span></td></tr>
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'''The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)'''
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6q OCA], [https://pdbe.org/2f6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f6q RCSB], [https://www.ebi.ac.uk/pdbsum/2f6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f6q ProSAT]</span></td></tr>
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</table>
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== Function ==
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==About this Structure==
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[[https://www.uniprot.org/uniprot/ECI2_HUMAN ECI2_HUMAN]] Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity).
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2F6Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6Q OCA].
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/2f6q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f6q ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Dodecenoyl-CoA isomerase]]
[[Category: Dodecenoyl-CoA isomerase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith, C]]
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[[Category: Berridge, G.]]
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[[Category: Berridge, G]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A.]]
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[[Category: Edwards, A]]
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[[Category: Gileadi, O.]]
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[[Category: Gileadi, O]]
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[[Category: Guo, K.]]
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[[Category: Guo, K]]
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[[Category: Lukacik, P.]]
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[[Category: Lukacik, P]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann, U]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Shafqat, N.]]
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[[Category: Shafqat, N]]
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[[Category: Smee, C.]]
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[[Category: Smee, C]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom, M]]
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[[Category: Turnbull, A.]]
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[[Category: Turnbull, A]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Enoyl coa isomerase]]
[[Category: Enoyl coa isomerase]]
[[Category: Fatty acid metabolism]]
[[Category: Fatty acid metabolism]]
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[[Category: Isomerase]]
[[Category: Peroxisome]]
[[Category: Peroxisome]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:31:48 2008''
 

Current revision

The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)

PDB ID 2f6q

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