1drs
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1drs.gif|left|200px]] | [[Image:1drs.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1drs", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1drs| PDB=1drs | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN''' | '''THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN''' | ||
| Line 30: | Line 27: | ||
[[Category: Sutcliffe, M J.]] | [[Category: Sutcliffe, M J.]] | ||
[[Category: Williams, J A.]] | [[Category: Williams, J A.]] | ||
| - | [[Category: | + | [[Category: Cell adhesion protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:11:46 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:11, 2 May 2008
THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN
Overview
Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.
About this Structure
1DRS is a Single protein structure of sequence from Dendroaspis jamesoni kaimosae. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin., Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA, Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:7634091 Page seeded by OCA on Fri May 2 14:11:46 2008
