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1drz

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{{Structure
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{{STRUCTURE_1drz| PDB=1drz | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1drz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drz OCA], [http://www.ebi.ac.uk/pdbsum/1drz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1drz RCSB]</span>
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'''U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX'''
'''U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX'''
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[[Category: Doudna, J A.]]
[[Category: Doudna, J A.]]
[[Category: Zhou, K.]]
[[Category: Zhou, K.]]
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[[Category: catalytic rna]]
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[[Category: Catalytic rna]]
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[[Category: hdv]]
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[[Category: Hdv]]
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[[Category: ribozyme]]
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[[Category: Ribozyme]]
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[[Category: rna-binding protein]]
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[[Category: Rna-binding protein]]
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[[Category: u1a]]
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[[Category: U1a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:47:27 2008''
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Revision as of 11:12, 2 May 2008

Image:1drz.jpg

Template:STRUCTURE 1drz

U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX


Overview

The self-cleaving ribozyme of the hepatitis delta virus (HDV) is the only catalytic RNA known to be required for the viability of a human pathogen. We obtained crystals of a 72-nucleotide, self-cleaved form of the genomic HDV ribozyme that diffract X-rays to 2.3 A resolution by engineering the RNA to bind a small, basic protein without affecting ribozyme activity. The co-crystal structure shows that the compact catalytic core comprises five helical segments connected as an intricate nested double pseudoknot. The 5'-hydroxyl leaving group resulting from the self-scission reaction is buried deep within an active-site cleft produced by juxtaposition of the helices and five strand-crossovers, and is surrounded by biochemically important backbone and base functional groups in a manner reminiscent of protein enzymes.

About this Structure

1DRZ is a Single protein structure of sequence from Hepatitis delta virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a hepatitis delta virus ribozyme., Ferre-D'Amare AR, Zhou K, Doudna JA, Nature. 1998 Oct 8;395(6702):567-74. PMID:9783582 Page seeded by OCA on Fri May 2 14:12:10 2008

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