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2fbe
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2fbe" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fbe, resolution 2.52Å" /> '''Crystal Structure o...) |
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| - | [[Image:2fbe.gif|left|200px]]<br /> | ||
| - | <applet load="2fbe" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2fbe, resolution 2.52Å" /> | ||
| - | '''Crystal Structure of the PRYSPRY-domain'''<br /> | ||
| - | == | + | ==Crystal Structure of the PRYSPRY-domain== |
| - | We determined the first structure of PRYSPRY, a domain found in over 500 | + | <StructureSection load='2fbe' size='340' side='right'caption='[[2fbe]], [[Resolution|resolution]] 2.52Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2fbe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FBE FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gene 19q13.4.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fbe OCA], [https://pdbe.org/2fbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fbe RCSB], [https://www.ebi.ac.uk/pdbsum/2fbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fbe ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fb/2fbe_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fbe ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site. | ||
| - | + | Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.,Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311<ref>PMID:16364311</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 2fbe" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: Briand, C | + | <references/> |
| - | [[Category: Capitani, G | + | __TOC__ |
| - | [[Category: Gruetter, C | + | </StructureSection> |
| - | [[Category: Gruetter, M | + | [[Category: Human]] |
| - | [[Category: Mittl, P | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Briand, C]] |
| - | [[Category: | + | [[Category: Capitani, G]] |
| - | + | [[Category: Gruetter, C]] | |
| - | + | [[Category: Gruetter, M G]] | |
| + | [[Category: Mittl, P R]] | ||
| + | [[Category: Dimer]] | ||
| + | [[Category: Jellyroll beta-sandwich fold]] | ||
| + | [[Category: Unknown function]] | ||
Current revision
Crystal Structure of the PRYSPRY-domain
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