Sandbox GGC9

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Function

RAG1 and RAG2 form the RAG Complex, which is responsible for regulating the DNA cleavage phase during recombination. V(D)J recombination functions to produce a plethora of immune molecules (antibodies) in developing B and T-lymphocytes. The V stands for variable, D, diversity and J joining. RAG1 functions as the catalytic component while RAG2, although not catalytic, is required for RAG1 to function.

Disease

Relevance

Structural highlights

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