PROTAC

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PROTAC (Proteolysis-Targeting Chimera) is a small protein with two active domains joined by a linker.
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A Proteolysis-Targeting Chimera (PROTAC) is a small protein with two active domains joined by a linker. PROTACs represent an alternative to conventional enzyme inhibitors, by enabling [[Proteasome|proteasome]] induced degradation of the target protein.
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[[Image:PROTAC_70.png|thumb|right|300px|Representative PROTAC from [https://protacpedia.weizmann.ac.il/ptcb/detp?i=70 PROTACpedia] targeting EGFR Epidermal growth factor receptor P00533. <span class="bg-lightblue"><b>target binding ligand</b></span><span class="bg-lightmagenta"><b>linker</b></span><span class="bg-lightgreen"><b>E3 binder</b></span>]]
[[Image:PROTAC_70.png|thumb|right|300px|Representative PROTAC from [https://protacpedia.weizmann.ac.il/ptcb/detp?i=70 PROTACpedia] targeting EGFR Epidermal growth factor receptor P00533. <span class="bg-lightblue"><b>target binding ligand</b></span><span class="bg-lightmagenta"><b>linker</b></span><span class="bg-lightgreen"><b>E3 binder</b></span>]]

Revision as of 08:16, 28 February 2021

A Proteolysis-Targeting Chimera (PROTAC) is a small protein with two active domains joined by a linker. PROTACs represent an alternative to conventional enzyme inhibitors, by enabling proteasome induced degradation of the target protein.

Representative PROTAC from PROTACpedia targeting EGFR Epidermal growth factor receptor P00533. target binding ligandlinkerE3 binder
Representative PROTAC from PROTACpedia targeting EGFR Epidermal growth factor receptor P00533. target binding ligandlinkerE3 binder

Predicting PROTACs

PRosettaC [1] is a computational protocol for the prediction of PROTAC-induced ternary complexes [2]. The protocol receives as input, two protein structures (protein target and E3 ligase), including their appropriate ligands (binders), as well as the PROTAC chemical structure in a SMILES representation, and outputs predicted models for the ternary complex.

PROTACpedia

PROTACpedia [3] is a collaborative and comprehensive, high-quality and freely accessible resource of manually curated data on Proteolysis Targeting Chimeras (PROTACs).

References

  1. ↑ PRosettaC https://prosettac.weizmann.ac.il
  2. ↑ Zaidman D, Prilusky J, London N. PRosettaC: Rosetta based modeling of PROTAC mediated ternary complexes. J Chem Inf Model. 2020 Sep 25. doi: 10.1021/acs.jcim.0c00589. PMID:32976709 doi:http://dx.doi.org/10.1021/acs.jcim.0c00589
  3. ↑ PROTACpedia https://protacpedia.weizmann.ac.il/

Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky

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