Sandbox GGC2
From Proteopedia
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== Function == | == Function == | ||
| - | <scene name='75/752269/Oliver_main/1'>Human Hexokinase 1 '1QHA'</scene> falls under the protein category of a kinase. A kinase is a protein that is responsible for the modification of a molecule through the covalent addition of the phosphate group. The source of the phosphate group is <scene name='75/752269/Oliver_atp/2'>Adenosine Triphosphate (ATP)</scene>. Human Hexokinase 1 catalyzes the phosphorylation of hexose sugars, primarily <scene name='75/752269/Oliver_glucose/2'>Glucose</scene> to form Glucose-6-Phosphate. This is typically observed during the initial step of glycolysis and is performed in order to attach a charge to the glucose, preventing it from diffusing out of the cell through the cell membrane. Typically, a <scene name='75/752269/Oliver_magnesium/1'>Magnesium (Mg<sup>2+</sup>)</scene> cofactor also participates in a chelation complex with ATP <ref>PMID:2931560</ref>. | + | <scene name='75/752269/Oliver_main/1'>Human Hexokinase 1 '1QHA'</scene> falls under the protein category of a kinase. A kinase is a protein that is responsible for the modification of a molecule through the covalent addition of the phosphate group. The source of the phosphate group is <scene name='75/752269/Oliver_atp/2'>Adenosine Triphosphate (ATP)</scene>. Human Hexokinase 1 catalyzes the phosphorylation of hexose sugars, primarily <scene name='75/752269/Oliver_glucose/2'>Glucose</scene> to form Glucose-6-Phosphate. This is typically observed during the initial step of glycolysis and is performed in order to attach a charge to the glucose, preventing it from diffusing out of the cell through the cell membrane. Typically, a <scene name='75/752269/Oliver_magnesium/1'>Magnesium (Mg <sup>2+</sup> )</scene> cofactor also participates in a chelation complex with ATP <ref>PMID:2931560</ref>. |
Human Hexokinase 1 is also seen to have a function in both innate immunity and inflammation in which the protein acts as a pattern recognition receptor for N-acetyl-D-glucosamine, a hexose present in the peptidoglycan layer of bacterial cell walls. Upon binding to N-acetyl-D-glucosamine, Human Hexokinase 1 dissociates from the mitochondria, which results in the activation of NLRP3 inflammasome <ref>PMID:27374331</ref>. | Human Hexokinase 1 is also seen to have a function in both innate immunity and inflammation in which the protein acts as a pattern recognition receptor for N-acetyl-D-glucosamine, a hexose present in the peptidoglycan layer of bacterial cell walls. Upon binding to N-acetyl-D-glucosamine, Human Hexokinase 1 dissociates from the mitochondria, which results in the activation of NLRP3 inflammasome <ref>PMID:27374331</ref>. | ||
Revision as of 17:45, 28 February 2021
1QHA HUMAN HEXOKINASE TYPE I
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Garfinkel L, Garfinkel D. Magnesium regulation of the glycolytic pathway and the enzymes involved. Magnesium. 1985;4(2-3):60-72. PMID:2931560
- ↑ Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM. Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell. 2016 Jul 28;166(3):624-636. doi: 10.1016/j.cell.2016.05.076. Epub 2016 Jun , 30. PMID:27374331 doi:http://dx.doi.org/10.1016/j.cell.2016.05.076
