1dth

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[[Image:1dth.gif|left|200px]]
[[Image:1dth.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dth |SIZE=350|CAPTION= <scene name='initialview01'>1dth</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1dth", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CAA:Ca+Ion+Binding+Site'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Ion+Binding+Site'>CAB</scene>, <scene name='pdbsite=ZNA:Zn+Binding+Site'>ZNA</scene> and <scene name='pdbsite=ZNB:Zn+Binding+Site'>ZNB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Atrolysin_C Atrolysin C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.42 3.4.24.42] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1dth| PDB=1dth | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dth OCA], [http://www.ebi.ac.uk/pdbsum/1dth PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dth RCSB]</span>
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}}
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'''METALLOPROTEASE'''
'''METALLOPROTEASE'''
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[[Category: Scapozza, L.]]
[[Category: Scapozza, L.]]
[[Category: Zhang, D.]]
[[Category: Zhang, D.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: metalloprotease]]
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[[Category: Metalloprotease]]
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[[Category: venom]]
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[[Category: Venom]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:15:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:48:18 2008''
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Revision as of 11:15, 2 May 2008

Image:1dth.gif

Template:STRUCTURE 1dth

METALLOPROTEASE


Overview

Matrix metalloproteinase enzymes have been implicated in degenerative processes like tumor cell invasion, metastasis, and arthritis. Specific metalloproteinase inhibitors have been used to block tumor cell proliferation. We have examined the interaction of batimastat (BB-94) with a metalloproteinase [atrolysin C (Ht-d), EC 3.4.24.42] active site at 2.0-angstroms resolution (R = 16.8%). The title structure exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. This unprecedented binding geometry dramatizes the significance of the cavernous primary specificity site, pointing the way for the design of a new generation of potential antitumor drugs.

About this Structure

1DTH is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

Reference

Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding., Botos I, Scapozza L, Zhang D, Liotta LA, Meyer EF, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. PMID:8610113 Page seeded by OCA on Fri May 2 14:15:17 2008

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OCA

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