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6y3i
From Proteopedia
(Difference between revisions)
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==NMR solution structure of the hazelnut allergen Cor a 1.0402== | ==NMR solution structure of the hazelnut allergen Cor a 1.0402== | ||
| - | <StructureSection load='6y3i' size='340' side='right'caption='[[6y3i]]' scene=''> | + | <StructureSection load='6y3i' size='340' side='right'caption='[[6y3i]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[6y3i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corav Corav]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y3I FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y3i OCA], [https://pdbe.org/6y3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y3i RCSB], [https://www.ebi.ac.uk/pdbsum/6y3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y3i ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y3i OCA], [https://pdbe.org/6y3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y3i RCSB], [https://www.ebi.ac.uk/pdbsum/6y3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y3i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A major proportion of allergic reactions to hazelnuts (Corylus avellana) are caused by immunologic cross-reactivity of IgE antibodies to pathogenesis-related class 10 (PR-10) proteins. Intriguingly, the four known isoforms of the hazelnut PR-10 allergen Cor a 1, denoted as Cor a 1.0401-Cor a 1.0404, share sequence identities exceeding 97% but possess different immunologic properties. In this work we describe the NMR solution structures of these proteins and provide an in-depth study of their biophysical properties. Despite sharing highly similar three-dimensional structures, the four isoforms exhibit remarkable differences regarding structural flexibility, hydrogen bonding and thermal stability. Our experimental data reveal an inverse relation between structural flexibility and IgE-binding in ELISA experiments, with the most flexible isoform having the lowest IgE-binding potential, while the isoform with the most rigid backbone scaffold displays the highest immunologic reactivity. These results point towards a significant entropic contribution to the process of antibody binding. | ||
| + | |||
| + | Inverse relation between structural flexibility and IgE reactivity of Cor a 1 hazelnut allergens.,Fuhrer S, Kamenik AS, Zeindl R, Nothegger B, Hofer F, Reider N, Liedl KR, Tollinger M Sci Rep. 2021 Feb 18;11(1):4173. doi: 10.1038/s41598-021-83705-z. PMID:33603065<ref>PMID:33603065</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6y3i" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Corav]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Fuehrer S]] | + | [[Category: Fuehrer, S]] |
| - | [[Category: Hofer F]] | + | [[Category: Hofer, F]] |
| - | [[Category: Kamenik | + | [[Category: Kamenik, A S]] |
| - | [[Category: Liedl | + | [[Category: Liedl, K R]] |
| - | [[Category: Nothegger B]] | + | [[Category: Nothegger, B]] |
| - | [[Category: Reider N]] | + | [[Category: Reider, N]] |
| - | [[Category: Tollinger M]] | + | [[Category: Tollinger, M]] |
| - | [[Category: Zeindl R]] | + | [[Category: Zeindl, R]] |
| + | [[Category: Allergen]] | ||
| + | [[Category: Hazelnut allergen]] | ||
| + | [[Category: Pr-10 related protein]] | ||
Current revision
NMR solution structure of the hazelnut allergen Cor a 1.0402
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