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1cz6

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Revision as of 15:20, 3 March 2021

SOLUTION STRUCTURE OF ANDROCTONIN

Structural highlights

1cz6 is a 1 chain structure with sequence from Androctonus australis. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ANDT_ANDAU] Active against both bacteria (Gram-positive and Gram-negative) and filamentous fungi. Acts on the membrane of the bacterial cells. It destabilize a membrane by modifying its properties.

Publication Abstract from PubMed

Androctonin is a highly cationic antimicrobial peptide from scorpion exhibiting a broad spectrum of activities against bacteria and fungi. It contains 25 amino acids including four cysteine residues forming two disulfide bridges. We report here on the determination of its solution structure by conventional two-dimensional (2D) 1H-NMR spectroscopy and molecular modelling using distance geometry and molecular dynamics methods. The structure of androctonin involves a well-defined highly twisted anti-parallel beta-sheet with strands connected by a more variable positively charged turn. A comparison with the structure of tachyplesin I (horseshoe crab) reveals that the amphiphilic character of the protein surface of this homologous peptide is not observed in androctonin. We have undertaken a 200-ps molecular dynamics simulation study on a system including one androctonin molecule and a monolayer of DMPG (1,2-dimyristoylphosphatidylglycerol) lipids. On the basis of this simulation, the first steps of the membrane permeabilization process are discussed.

Androctonin, a novel antimicrobial peptide from scorpion Androctonus australis: solution structure and molecular dynamics simulations in the presence of a lipid monolayer.,Mandard N, Sy D, Maufrais C, Bonmatin JM, Bulet P, Hetru C, Vovelle F J Biomol Struct Dyn. 1999 Oct;17(2):367-80. PMID:10563585^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Mandard N, Sy D, Maufrais C, Bonmatin JM, Bulet P, Hetru C, Vovelle F. Androctonin, a novel antimicrobial peptide from scorpion Androctonus australis: solution structure and molecular dynamics simulations in the presence of a lipid monolayer. J Biomol Struct Dyn. 1999 Oct;17(2):367-80. PMID:10563585

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1cz6"

@@ Line 3: / Line 3: @@
 <StructureSection load='1cz6' size='340' side='right'caption='[[1cz6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1cz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1CZ6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1cz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_australis Androctonus australis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CZ6 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cz6 OCA], [http://pdbe.org/1cz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1cz6 RCSB], [http://www.ebi.ac.uk/pdbsum/1cz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1cz6 ProSAT]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cz6 OCA], [https://pdbe.org/1cz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cz6 RCSB], [https://www.ebi.ac.uk/pdbsum/1cz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cz6 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ANDT_ANDAU ANDT_ANDAU]] Active against both bacteria (Gram-positive and Gram-negative) and filamentous fungi. Acts on the membrane of the bacterial cells. It destabilize a membrane by modifying its properties.
+[[https://www.uniprot.org/uniprot/ANDT_ANDAU ANDT_ANDAU]] Active against both bacteria (Gram-positive and Gram-negative) and filamentous fungi. Acts on the membrane of the bacterial cells. It destabilize a membrane by modifying its properties.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

1cz6

From Proteopedia

Revision as of 15:20, 3 March 2021

SOLUTION STRUCTURE OF ANDROCTONIN

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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