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2fvz
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2fvz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fvz, resolution 2.400Å" /> '''Human Inositol Mon...) |
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| - | [[Image:2fvz.gif|left|200px]]<br /> | ||
| - | <applet load="2fvz" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2fvz, resolution 2.400Å" /> | ||
| - | '''Human Inositol Monophosphosphatase 2'''<br /> | ||
| - | == | + | ==Human Inositol Monophosphosphatase 2== |
| - | + | <StructureSection load='2fvz' size='340' side='right'caption='[[2fvz]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2fvz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPA2, IMP.18P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvz OCA], [https://pdbe.org/2fvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvz RCSB], [https://www.ebi.ac.uk/pdbsum/2fvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvz ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | + | [[https://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN]] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | [ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fvz_consurf.spt"</scriptWhenChecked> | |
| - | [[ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fvz ConSurf]. | |
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| - | + | ==See Also== | |
| + | *[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Inositol-phosphate phosphatase]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C]] | ||
| + | [[Category: Berg, S Van Den]] | ||
| + | [[Category: Berglund, H]] | ||
| + | [[Category: Collins, R]] | ||
| + | [[Category: Edwards, A]] | ||
| + | [[Category: Ehn, M]] | ||
| + | [[Category: Flodin, S]] | ||
| + | [[Category: Graslund, S]] | ||
| + | [[Category: Hallberg, B M]] | ||
| + | [[Category: Hammarstrom, M]] | ||
| + | [[Category: Hogbom, M]] | ||
| + | [[Category: Holmberg-Schiavone, L]] | ||
| + | [[Category: Kotenyova, T]] | ||
| + | [[Category: Kursula, P]] | ||
| + | [[Category: Nilsson-Ehle, P]] | ||
| + | [[Category: Nordlund, P]] | ||
| + | [[Category: Nyman, T]] | ||
| + | [[Category: Ogg, D]] | ||
| + | [[Category: Persson, C]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Sagemark, J]] | ||
| + | [[Category: Stenmark, P]] | ||
| + | [[Category: Sundstrom, M]] | ||
| + | [[Category: Thorsell, A G]] | ||
| + | [[Category: Weigelt, J]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inositol metabolism]] | ||
| + | [[Category: Inositol monophosphatase]] | ||
| + | [[Category: Sgc]] | ||
Current revision
Human Inositol Monophosphosphatase 2
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Categories: Human | Inositol-phosphate phosphatase | Large Structures | Arrowsmith, C | Berg, S Van Den | Berglund, H | Collins, R | Edwards, A | Ehn, M | Flodin, S | Graslund, S | Hallberg, B M | Hammarstrom, M | Hogbom, M | Holmberg-Schiavone, L | Kotenyova, T | Kursula, P | Nilsson-Ehle, P | Nordlund, P | Nyman, T | Ogg, D | Persson, C | Structural genomic | Sagemark, J | Stenmark, P | Sundstrom, M | Thorsell, A G | Weigelt, J | Hydrolase | Inositol metabolism | Inositol monophosphatase | Sgc
