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2fvz

From Proteopedia

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{{Seed}}
 
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[[Image:2fvz.png|left|200px]]
 
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<!--
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==Human Inositol Monophosphosphatase 2==
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The line below this paragraph, containing "STRUCTURE_2fvz", creates the "Structure Box" on the page.
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<StructureSection load='2fvz' size='340' side='right'caption='[[2fvz]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fvz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FVZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IMPA2, IMP.18P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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-->
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
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{{STRUCTURE_2fvz| PDB=2fvz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fvz OCA], [https://pdbe.org/2fvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fvz RCSB], [https://www.ebi.ac.uk/pdbsum/2fvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fvz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/IMPA2_HUMAN IMPA2_HUMAN]] Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.<ref>PMID:17068342</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fvz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fvz ConSurf].
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<div style="clear:both"></div>
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===Human Inositol Monophosphosphatase 2===
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==See Also==
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*[[Inositol monophosphatase 3D structures|Inositol monophosphatase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2FVZ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVZ OCA].
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__TOC__
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[[Category: Homo sapiens]]
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</StructureSection>
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[[Category: Human]]
[[Category: Inositol-phosphate phosphatase]]
[[Category: Inositol-phosphate phosphatase]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Berg, S Van Den.]]
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[[Category: Arrowsmith, C]]
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[[Category: Berglund, H.]]
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[[Category: Berg, S Van Den]]
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[[Category: Collins, R.]]
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[[Category: Berglund, H]]
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[[Category: Edwards, A.]]
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[[Category: Collins, R]]
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[[Category: Ehn, M.]]
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[[Category: Edwards, A]]
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[[Category: Flodin, S.]]
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[[Category: Ehn, M]]
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[[Category: Graslund, S.]]
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[[Category: Flodin, S]]
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[[Category: Hallberg, B M.]]
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[[Category: Graslund, S]]
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[[Category: Hammarstrom, M.]]
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[[Category: Hallberg, B M]]
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[[Category: Hogbom, M.]]
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[[Category: Hammarstrom, M]]
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[[Category: Holmberg-Schiavone, L.]]
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[[Category: Hogbom, M]]
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[[Category: Kotenyova, T.]]
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[[Category: Holmberg-Schiavone, L]]
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[[Category: Kursula, P.]]
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[[Category: Kotenyova, T]]
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[[Category: Nilsson-Ehle, P.]]
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[[Category: Kursula, P]]
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[[Category: Nordlund, P.]]
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[[Category: Nilsson-Ehle, P]]
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[[Category: Nyman, T.]]
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[[Category: Nordlund, P]]
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[[Category: Ogg, D.]]
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[[Category: Nyman, T]]
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[[Category: Persson, C.]]
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[[Category: Ogg, D]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Persson, C]]
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[[Category: Sagemark, J.]]
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[[Category: Structural genomic]]
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[[Category: Stenmark, P.]]
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[[Category: Sagemark, J]]
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[[Category: Sundstrom, M.]]
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[[Category: Stenmark, P]]
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[[Category: Thorsell, A G.]]
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[[Category: Sundstrom, M]]
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[[Category: Weigelt, J.]]
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[[Category: Thorsell, A G]]
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[[Category: Weigelt, J]]
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[[Category: Hydrolase]]
[[Category: Inositol metabolism]]
[[Category: Inositol metabolism]]
[[Category: Inositol monophosphatase]]
[[Category: Inositol monophosphatase]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:44:07 2009''
 

Current revision

Human Inositol Monophosphosphatase 2

PDB ID 2fvz

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