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5z5k

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Current revision (17:41, 10 March 2021) (edit) (undo)
 
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<StructureSection load='5z5k' size='340' side='right'caption='[[5z5k]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
<StructureSection load='5z5k' size='340' side='right'caption='[[5z5k]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5z5k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z5K OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Z5K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5z5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z5K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dcc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Draxin, DRAXIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dcc ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Draxin, DRAXIN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5z5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z5k OCA], [http://pdbe.org/5z5k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z5k RCSB], [http://www.ebi.ac.uk/pdbsum/5z5k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z5k ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z5k OCA], [https://pdbe.org/5z5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z5k RCSB], [https://www.ebi.ac.uk/pdbsum/5z5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z5k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DCC_RAT DCC_RAT]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity).<ref>PMID:8861902</ref> [[http://www.uniprot.org/uniprot/D3ZDG4_RAT D3ZDG4_RAT]] Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.[HAMAP-Rule:MF_03060]
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[[https://www.uniprot.org/uniprot/DCC_RAT DCC_RAT]] Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity).<ref>PMID:8861902</ref> [[https://www.uniprot.org/uniprot/D3ZDG4_RAT D3ZDG4_RAT]] Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.[HAMAP-Rule:MF_03060]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Liu, Y]]
[[Category: Liu, Y]]
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[[Category: Wang, J]]
[[Category: Xiao, J]]
[[Category: Xiao, J]]
[[Category: Apoptosis-inbititor complex]]
[[Category: Apoptosis-inbititor complex]]
[[Category: Axon guidance]]
[[Category: Axon guidance]]

Current revision

Structure of the DCC-Draxin complex

PDB ID 5z5k

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OCA

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