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2g7r

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[[Image:2g7r.gif|left|200px]]
 
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{{Structure
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==X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1==
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|PDB= 2g7r |SIZE=350|CAPTION= <scene name='initialview01'>2g7r</scene>, resolution 2.70&Aring;
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<StructureSection load='2g7r' size='340' side='right'caption='[[2g7r]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2g7r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G7R FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MALT1, MLT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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|GENE= MALT1, MLT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7r OCA], [https://pdbe.org/2g7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g7r RCSB], [https://www.ebi.ac.uk/pdbsum/2g7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g7r ProSAT]</span></td></tr>
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}}
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</table>
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== Disease ==
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'''X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1'''
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[[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
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== Function ==
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[[https://www.uniprot.org/uniprot/MALT1_HUMAN MALT1_HUMAN]] Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.<ref>PMID:11262391</ref> <ref>PMID:14695475</ref> <ref>PMID:18264101</ref>
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==Disease==
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== Evolutionary Conservation ==
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Known diseases associated with this structure: MALT lymphoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604860 604860]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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2G7R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G7R OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/2g7r_consurf.spt"</scriptWhenChecked>
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[[Category: Homo sapiens]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Single protein]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Arrowsmith, C.]]
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</jmolCheckbox>
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[[Category: Bochkarev, A.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g7r ConSurf].
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[[Category: Butler-Cole, C.]]
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<div style="clear:both"></div>
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[[Category: Dhe-Paganon, S.]]
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== References ==
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[[Category: Edwards, A.]]
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<references/>
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[[Category: Jr., P J.Finerty.]]
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__TOC__
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[[Category: Newman, E M.]]
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</StructureSection>
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Human]]
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[[Category: Sundstrom, M.]]
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[[Category: Large Structures]]
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[[Category: Walker, J R.]]
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[[Category: Arrowsmith, C]]
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[[Category: Weigelt, J.]]
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[[Category: Bochkarev, A]]
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[[Category: Wybenga-Groot, L.]]
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[[Category: Butler-Cole, C]]
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[[Category: alternative splicing]]
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[[Category: Dhe-Paganon, S]]
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[[Category: chromosomal translocation]]
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[[Category: Edwards, A]]
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[[Category: death domain]]
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[[Category: Finerty, P J]]
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[[Category: hydrolase]]
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[[Category: Newman, E M]]
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[[Category: protease]]
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[[Category: Structural genomic]]
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[[Category: sgc]]
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[[Category: Sundstrom, M]]
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[[Category: structural genomics consortium]]
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[[Category: Walker, J R]]
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[[Category: Weigelt, J]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:01:26 2008''
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[[Category: Wybenga-Groot, L]]
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[[Category: Chromosomal translocation]]
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[[Category: Death domain]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Sgc]]

Current revision

X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1

PDB ID 2g7r

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OCA

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