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2gg8

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==Novel bacterial methionine aminopeptidase inhibitors==
==Novel bacterial methionine aminopeptidase inhibitors==
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<StructureSection load='2gg8' size='340' side='right' caption='[[2gg8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='2gg8' size='340' side='right'caption='[[2gg8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2gg8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GG8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2gg8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GG8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=U15:METHYL+N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-METHYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE'>U15</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=U15:METHYL+N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-METHYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE'>U15</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gg0|2gg0]], [[2gg2|2gg2]], [[2gg3|2gg3]], [[2gg5|2gg5]], [[2gg7|2gg7]], [[2gg9|2gg9]], [[2ggb|2ggb]], [[2ggc|2ggc]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gg0|2gg0]], [[2gg2|2gg2]], [[2gg3|2gg3]], [[2gg5|2gg5]], [[2gg7|2gg7]], [[2gg9|2gg9]], [[2ggb|2ggb]], [[2ggc|2ggc]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">map ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">map ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gg8 OCA], [http://pdbe.org/2gg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gg8 RCSB], [http://www.ebi.ac.uk/pdbsum/2gg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gg8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gg8 OCA], [https://pdbe.org/2gg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gg8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gg8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AMPM_ECOLI AMPM_ECOLI]] Removes the N-terminal methionine from nascent proteins.
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[[https://www.uniprot.org/uniprot/AMPM_ECOLI AMPM_ECOLI]] Removes the N-terminal methionine from nascent proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Aminopeptidase|Aminopeptidase]]
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Ecoli]]
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[[Category: Large Structures]]
[[Category: Methionyl aminopeptidase]]
[[Category: Methionyl aminopeptidase]]
[[Category: Evdokimov, A G]]
[[Category: Evdokimov, A G]]

Revision as of 19:02, 10 March 2021

Novel bacterial methionine aminopeptidase inhibitors

PDB ID 2gg8

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