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6nb7

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==SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)==
==SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)==
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<StructureSection load='6nb7' size='340' side='right' caption='[[6nb7]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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<SX load='6nb7' size='340' side='right' viewer='molstar' caption='[[6nb7]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6nb7]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvhsa Cvhsa] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NB7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NB7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6nb7]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NB7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nb3|6nb3]], [[6nb4|6nb4]], [[6nb5|6nb5]], [[6nb6|6nb6]], [[6nb8|6nb8]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6nb3|6nb3]], [[6nb4|6nb4]], [[6nb5|6nb5]], [[6nb6|6nb6]], [[6nb8|6nb8]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S, 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 CVHSA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nb7 OCA], [https://pdbe.org/6nb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nb7 RCSB], [https://www.ebi.ac.uk/pdbsum/6nb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nb7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nb7 OCA], [http://pdbe.org/6nb7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nb7 RCSB], [http://www.ebi.ac.uk/pdbsum/6nb7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nb7 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
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[[https://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6nb7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6nb7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sandbox 3001|Sandbox 3001]]
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*[[Spike protein|Spike protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Cvhsa]]
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[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Cameroni, E]]
[[Category: Cameroni, E]]
[[Category: Corti, D]]
[[Category: Corti, D]]

Current revision

SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)

6nb7, resolution 4.50Å

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