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1dyq

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[[Image:1dyq.gif|left|200px]]
[[Image:1dyq.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1dyq |SIZE=350|CAPTION= <scene name='initialview01'>1dyq</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1dyq", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ZN1:Zn+Binding+Site+The+Zn+Ion+Is+Bound+To+Residues+HIS+A+18+...'>ZN1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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{{STRUCTURE_1dyq| PDB=1dyq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dyq OCA], [http://www.ebi.ac.uk/pdbsum/1dyq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dyq RCSB]</span>
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}}
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'''STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE'''
'''STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE'''
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[[Category: Rupp, B.]]
[[Category: Rupp, B.]]
[[Category: Segelke, B W.]]
[[Category: Segelke, B W.]]
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[[Category: enterotoxin]]
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[[Category: Enterotoxin]]
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[[Category: staphylococcal enterotoxin type some]]
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[[Category: Staphylococcal enterotoxin type some]]
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[[Category: vaccine]]
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[[Category: Vaccine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:26:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:51:41 2008''
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Revision as of 11:26, 2 May 2008

Image:1dyq.gif

Template:STRUCTURE 1dyq

STAPHYLOCOCCAL ENTEROTOXIN A MUTANT VACCINE


Overview

Staphylococcal enterotoxins (SEs) are superantigenic protein toxins responsible for a number of life-threatening diseases. The X-ray structure of a staphylococcal enterotoxin A (SEA) triple-mutant (L48R, D70R, and Y92A) vaccine reveals a cascade of structural rearrangements located in three loop regions essential for binding the alpha subunit of major histocompatibility complex class II (MHC-II) molecules. A comparison of hypothetical model complexes between SEA and the SEA triple mutant with MHC-II HLA-DR1 clearly shows disruption of key ionic and hydrophobic interactions necessary for forming the complex. Extensive dislocation of the disulfide loop in particular interferes with MHC-IIalpha binding. The triple-mutant structure provides new insights into the loss of superantigenicity and toxicity of an engineered superantigen and provides a basis for further design of enterotoxin vaccines.

About this Structure

1DYQ is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIalpha., Krupka HI, Segelke BW, Ulrich RG, Ringhofer S, Knapp M, Rupp B, Protein Sci. 2002 Mar;11(3):642-51. PMID:11847286 Page seeded by OCA on Fri May 2 14:26:40 2008

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